Protein Engineering and Design

ISBN-13: 9781420076585 / Angielski / Twarda / 2009 / 416 str.

Sheldon J. Park; Jennifer R. Cochran

Opis

The cutting-edge development of using a computational design approach as a means of engineering proteins with novel functions has led to widespread usage of computational analysis in protein engineering at large. However, because the structure and function of protein molecules are coupled at the molecular level, many critical questions are left unanswered and many of the intricate design rules unclear. This book furthers understanding in this complex design area by using lucid description of computation's role in protein engineering and tracing the history of protein design. In so doing, it successfully de-mystifies computational analysis, thereby making it widely accessible to a broad audience both in academia and industry.

Spis treści

Phage Display Systems for Protein Engineering. Cell Surface Display Systems for Protein Engineering. Cell-Free Display Systems for Protein Engineering. Library Construction for Protein Engineering. Design and Engineering of Synthetic Binding Proteins Using Nonantibody Scaffolds. Combinatorial Enzyme Engineering. Engineering of Therapeutic Proteins. Protein Engineered Biomaterials. Protein Engineering Using Noncanonical Amino Acids. Computer Graphics, Homology Modeling, and Bioinformatics. Knowledge-Based Protein Design. Molecular Force Fields. Rotamer Libraries for Molecular Modeling and Design of Proteins. Search Algorithms. Modulating Protein Structure. Modulation of Intrinsic Properties by Computational Design. Modulating Protein Interactions by Rational and Computational Design. Future Challenges of Computational Protein Design.