A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address...

This study presents innovative work from four core areas: phonological representations and the lexicon; phonetic interpretation and phrasal structure; phonetic interpretation and syllable structure; and phonology and natural speech production. Written by experts in the fields of phonetics, phonology and speech perception, the chapters in this volume use a wide range of laboratory and instrumental techniques to analyze the production and perception of speech. They explore the relationship between the sounds of speech and the linguistic organization that lies behind them.

This book introduces undergraduates to the concepts, terminology and representations needed for an understanding of how English is pronounced around the world. Assuming no prior knowledge, the book guides readers through the vocal tract and explains how sounds of speech are made. Two main forms of representation are used: phonetic transcription and simple acoustic data. As far as possible, the book is based on naturally-occurring, conversational speech so that readers are familiar with the details of everyday talk (and not just the careful pronunciations represented in dictionaries). Examples...

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address...