Reverse Transcriptase Inhibitors in Hiv/AIDS Therapy

ISBN-13: 9781588296498 / Angielski / Twarda / 2006 / 527 str.

Gail Skowron; Richard Ogden; Joep M. A. Lange

Opis

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

Recenzje

From the reviews:

"This book will appeal to medical students needing a detailed review of area ... . It is most suitable for libraries ... . The individual chapters are authoritative and comprehensive ... . a source for in-depth and specific information." (Mark Harris, Microbiology Today, November, 2006)

Spis treści

Structural Studies on HIV Reverse Transcriptase Related to Drug Discovery David K. Stammers and Jingshan Ren Zidovudine, Lamivudine, and Abacavir Monica Carten and Harold Kessler Stavudine, Didanosine, and Zalcitabine Gail Skowron, Sapna Chowdhry, and Michael R. Stevens Emtricitabine Gail Skowron, Jeffrey Bratberg, and Rudi Pauwels Nucleotide Analogs Craig J. Hoesley Resistance to Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Nancy Shulman and Mark Winters Pharmacokinetics of Reverse Transcriptase Inhibitors Patrick Hoggard, Stephen Kewn, Saye Khoo and David Back Peripheral Neuropathy Associated With Nucleoside Reverse Transcriptase Inhibitor Therapy Bruce A. Cohen and Russell Bartt Mitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy: A Pathophysiological Perspective William Lewis Mitochondrial Toxicity and Lipodystrophy Grace McComsey Nevirapine David Asmuth and Richard Pollard Efavirenz Graeme J. Moyle and Brian Conway Delavirdine Brian Conway Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors F. Ramzi Asfour and Richard Haubrich Vertical Transmission of HIV and Therapeutic Interventions Susan Cu-Uvin, Arlene Bardeguez, and Carla Chibwesha New Reverse Transcriptase Inhibitors in Development Rudi Pauwels Antiretroviral Drugs for Millions Allan Ronald, Elly Katabira, and Merle Sande Postscript Richard Ogden and Gail Skowron Index

Blurb

Despite significant pharmacological advances, the backbone of the most highly active antiretroviral therapy regimens for controlling HIV/AIDS is still a combination of reverse transcriptase inhibitors (RTIs) first discovered in the late 1980s. In Reverse Transcriptase Inhibitors in HIV/AIDS Therapy, leading experts in AIDS/HIV drug discovery and development review all aspects of RTIs (nucleosides, nucleotides, and non-nucleosides), including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment in general, and on vertical transmission in the developing world. Highlights include a thorough discussion of side effects, resistance, and treatment in the third world.
Comprehensive and up-to-date, Reverse Transcriptase Inhibitors in HIIV/AIDS Therapy offers a magisterial survey of the discovery, clinical development, current use, and future possibilities of all drugs that treat HIV/AIDS by inhibiting the viral reverse transcriptase.