The cover of this book summarizes the central features of the sequestration hypothesis: Commonplace appearances seen in human coronary artery, fat stained in paraffin seetions by a new technique explained in Chapter Eleven, are arranged to suggest pathways of evolution toward atheroma. The hypothesis formulated and defended in the pages ofthis book is this: Fibroplasia progresses upward in column "a" from "la" to "3a" as a characteristic feature of aging. This starts sooner and progresses faster in men than in wornen. Numbers ofSMC's remain essentially constant so that fibroplasia per SMC...

This book is the first in many decades to address aging as a risk factor, and claims a broad range of success, giving previously unsuspected explanations. Most of the material here is outside of the usual range pursued in this active field during recent decades, and serves to open new avenues of inquiry into neglected topics. The mathematical treatment of the subject matter is daunting but rarely goes beyond the level of high school algebra. Furthermore, it is not necessary to master the mathematics in order to gasp the biological principles. This book provides observations and insights that...