The Role of Aging in Atherosclerosis: The Sequestration Hypothesis

ISBN-13: 9789048162659 / Angielski / Miękka / 2010 / 273 str.

R. E. Tracy

Opis

This book is the first in many decades to address aging as a risk factor, and claims a broad range of success, giving previously unsuspected explanations. Most of the material here is outside of the usual range pursued in this active field during recent decades, and serves to open new avenues of inquiry into neglected topics. The mathematical treatment of the subject matter is daunting but rarely goes beyond the level of high school algebra. Furthermore, it is not necessary to master the mathematics in order to gasp the biological principles. This book provides observations and insights that originate with this author, and much of this is new material not previously published. The topics addressed are chiefly the biology of aging, atherosclerosis, hypertension, and diabetes, including the microvascular features of these disorders. Anyone studying these topics will find the book compelling.

Spis treści

One: Introduction to the sequestration hypothesis. Two: The sampling theory of fibrotic arteriosclerosis. Three: Intrusion of atheroma into the most fibrotically thickened intimal sites. Four: Conditions for the intrusion of atheroma in coronary artery. Five: The size of the SMC realm assessed with the help of sampling theory. Six: Biased censoring of low SMC sites by atheroma in coronary artery. Seven: Biased sampling of low SMC sites by atheroma in thoracic aorta. Eight: SMC numbers at varying depths in intima of thoracic aorta. Nine: Histologic appearances of SMC clusters and realms. Ten: Direct imaging of the hypothetical quantity, sequestered lipid. Eleven: Local sequestration of lipid from place to place within an artery. Twelve: Fibroplasia in microscopic renal arteries. Thirteen: Parameters of fibroplasia in renal microvasculature. Fourteen: The course of arterial intimal fibroplasia in aging arteries. Fifteen: The course of fibroplasia per SMC over time in aging arteries. Sixteen: Fibroplasia per SMC in the media of coronary arteries. Seventeen: Influence of arteriolar hyalinization on renovascular fibroplasia. Eighteen: The Hy effect on Ra in widely variable circumstances. Nineteen: Hyalinized renal arterioles and the maleness coronary risk factor. Twenty: Two pathways to atheroma variably linked to renovasculopathies. Twenty One: Age of onset of the sex difference in coronary fibroplasias. Twenty Two: Adrenocortical nodularity in relation to coronary fibroplasia. Twenty Three: Atheroma and intimal fibroplasia in periodontal disease. Twenty Four: Atheroma and intimal fibroplasia in relation to obesity. Twenty Five: Paucity of literature relevant to SMC numbers and the aging risk factor.