A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of...

In this issue, the Guest Editors have focused on recent advances in liver disease related to disturbances in hemostasis and coagulation. The work emphasizes the multifaceted aspects of coagulation disorders in liver disease from hypo-coagulable to hyper-coagulable states and the limitations of conventional tests such as the INR to shed light on relative bleeding risk or on underlying pathophysiology in a given patient. Articles are written by leaders in the field from multiple disciplines and from around the world. In each article, the state of the art is discussed along with its limitations....

A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of...

Dr. Sanyal's expertise as Chairman of the Division of Hepatology at Virginia Commonwealth University and the breadth of his published articles in hepatology make him the perfect person to compile state-of-the-art reviews on the topic of NASH/fatty liver. The articles in this issue address the following topics: The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease; Relevance of Liver Histology to Predict Clinically Meaningful Outcomes in NASH; Mechanisms of Simple Hepatic Steatosis; Cellular and Molecular Basis for Phenotype of Steatohepatitis; Mechanisms of Disease Progression in NASH:...

Preceded by Zakim and Boyer's hepatology: a textbook of liver disease / [edited by] Thomas D. Boyer, Michael P. Manns, Arun J. Sanyal. 6th ed. c2012.