Portal Hypertension: Pathobiology, Evaluation, and Treatment

ISBN-13: 9781617375354 / Angielski / Miękka / 2010 / 528 str.

Arun J. Sanyal; Vijay H. Shah

Opis

A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.

Recenzje

"...truly insightful...the book beautifully builds upon the molecular and biological machinery into an enhanced clinical understanding of portal hypertension complete with the most up-to-date treatment options." - Practical Gastroenterology

"...provides exceptional reading material encompassing a broad range of topics on basic and clinical aspecgts of portal hypertension...strongly recommended to researchers, practicing physicians, trainees, and others with an interest in this subject." Weighted Numerical Score: 96 - 4 Stars! - Doody's Health Science Book Review Journal

"...the ideal guide for those who want to deal with the clinical problems of portal hypertension in a modern and effective way." - Digestive and Liver Disease

Spis treści

Part I. Historical Perspective Portal Hypertension: A History Adrian Reuben and Roberto J. Groszmann Part II. Pathobiology and Experimental Progress in Portal Hypertension Anatomy and Vascular Biology of the Cells in the Portal Circulation Massimo Pinzani and Francesco Vizzutti Cell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic Correlates Don C. Rockey Molecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of Cirrhosis Richard Moreau and Didier Lebrec Mechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunction in Cirrhosis Andrés Cárdenas and Pere Ginès Hepatic Hemodynamics in Portal Hypertension: Compliance, Hepatic Arterial Buffer Response, Hepatorenal Syndrome, and Liver Regeneration W. Wayne Lautt and Zhi Ming Neovascularization, Angiogenesis, and Vascular Remodeling in Portal Hypertension Manuel Morales-Ruiz and Wladimiro Jiménez Mechanisms of Cardiopulmonary Hemodynamics and Dysfunction in Portal Hypertension Michael B. Fallon Part III: Methodology to Assess Portal Hypertension in Humans Measurement of Hepatic Venous Pressure Gradient: Methods, Interpretation, and Pitfalls G. Pomier-Layrargues and P. Michel Huet Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques Juerg Reichen Endoscopic Assessment of Portal Hypertension Including Variceal Pressure Measurements: Methods, Interpretation, and Pitfalls Àngels Escorsell and Jaime Bosch Part IV: Natural History and Treatment of Esophageal Varices Clinical Features and Natural History of Variceal Hemorrhage: Implications for Surveillance and Screening Juan G. Abraldes and Jaime Bosch Management Strategies for the Prophylaxis and Treatment of Esophageal Variceal Rupture: AnOverview Roberto de Franchis Pharmacologic Therapy for the Management of Esophageal Varices: Biology and Utility of Available Agents Norman D. Grace and Richard S. Tilson Endoscopic Treatment for Bleeding Esophageal Varices John P. Cello Surgical Therapies for Management: Surgical Shunts and Liver Transplantation J. Michael Henderson Transjugular Intrahepatic Portosystemic Stent-Shunt: Technical Considerations and Clinical Utility in the Management of Variceal Hemorrhage Dhiraj Tripathi, Peter C. Hayes, Doris N. Redhead, and Rajiv Jalan Clinical Features and Management of Gastric Varices, Portal Hypertensive Gastropathy, and Ectopic Varices Charmaine A. Stewart and Patrick S. Kamath Part V: Natural History and Treatment of Ascites and Hepatorenal Syndrome Ascites: Clinical Features, Diagnosis, and Natural History Sakib Karim Khalid and Guadalupe Garcia-Tsao Management of Ascites Florence Wong Spontaneous Bacterial Peritonitis and Other Infections in Cirrhosis Rosa Maria Morillas and Ramon Planas Diagnosis and Management of the Hepatorenal Syndrome Kevin Moore Part V: Evaluation and Treatment in Special Circumstances of Portal Hypertension Pregnancy and Portal Hypertension Bimaljit Sandhu and Arun J. Sanyal Causes and Management of Portal Hypertension in the Pediatric Population Frederick C. Ryckman, Maria H. Alonso, and Greg Tiao Noncirrhotic Portal Hypertension and Portal Vein Thrombosis Shiv K. Sarin and Manav Wadhawan Hepatic Venous Outflow Obstruction: Budd-Chiari Syndrome and Veno-Occlusive Disease (Sinusoidal Obstruction Syndrome) Hugo E. Vargas and Thomas D. Boyer Pulmonary Complications Associated with Portal Hypertension Karen L. Swanson and Michael J. Krowka Health Status Assessment and Economic An

Blurb

Although the past several years have seen tremendous progress in both the understanding and clinical management of portal hypertension-a major complication of cirrhosis-many new therapies and pathogenic principles are now emerging that will lead to vastly improved therapeutic approaches in the years to come. In Portal Hypertension: Pathobiology, Evaluation, and Treatment, internationally renowned investigators and clinicians discuss the latest findings on key scientific topics and review the evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.
State-of-the-art and readily accessible, Portal Hypertension: Pathobiology, Evaluation, and Treatment provides both an authoritative reference for all gastroenterologists and an indispensable resource for all physicians treating liver disease, particularly in a tertiary care setting.