Adenosine 3,5 -cyclic monophosphate (cAMP) and guanosine 3,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first and second messengers. In concert with intracellular calcium and IP3, they play a major role in the control of intracellular signaling, which orchestrates normal and pathophysiological responses. Downstream from the cyclic nucleotide synthesis by adenylyl and guanylyl cyclases, the multigenic family of cyclic nucleotide phosphodiesterases (PDEs), by specifically hydrolyzing cyclic nucleotides, controls cAMP and cGMP levels to maintain a basal...

Adenosine 3,5 -cyclic monophosphate (cAMP) and guanosine 3,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first and second messengers. In concert with intracellular calcium and IP3, they play a major role in the control of intracellular signaling, which orchestrates normal and pathophysiological responses. Downstream from the cyclic nucleotide synthesis by adenylyl and guanylyl cyclases, the multigenic family of cyclic nucleotide phosphodiesterases (PDEs), by specifically hydrolyzing cyclic nucleotides, controls cAMP and cGMP levels to maintain a basal...

Les phosphodiestA(c)rases spA(c)cifiques des nuclA(c)otides cycliques (PDEs) sont constitue es par 11 familles gA(c)niques qui hydrolysent l''AMP cyclique (AMPc) et/ou le GMP cyclique (GMPc), seconds messagers intracellulaires. Du fait de la spA(c)cificitA(c) de la localisation tissulaire et subcellulaire des isoformes de PDE, l''inhibition se lective de l''hydrolyse de l''AMPc ou du GMPc par une isoforme altA(c)rA(c)e au cours d''un processus pathologique pourrait e tre induite spe cifiquement dans un tissu donne . Ainsi, l''inhibition sA(c)lective de l''isoforme altA(c)rA(c)e, normaliserait...