At the time when "Parkinson's Disease" is diagnosed in a patient, roughly two thirds of dopaminergic neurons of substantia nigra are already degenerated. The onset of the disease must, therefore, be much earlier. This book deals with early diagnosis and early preventive treatment which may sustain the process underlying the disease. By use of psychometric, kinesiologic, physiologic, histologic, biochemical, endocrinologic, pharmacologic and imaging techniques, including positron-emission tomography and brain mapping, specialists tried to focus on new diagnostic criteria. New methods including...
At the time when "Parkinson's Disease" is diagnosed in a patient, roughly two thirds of dopaminergic neurons of substantia nigra are already degenerat...
Walther Birkmayer, one of the co-discoverers of the neuro chemical causes of Parkinson's disease and of its treatment by neurotransmitter-replacement therapy, and his former col laborator and colleague Peter Riederer have succeeded in this book in giving us an outline and overview of current knowl edge of the biochemistry of the brain and synaptic transmis sion between nerve cells, together with an appreciation of how these factors relate to recent findings in human behavioural science, an area in which both authors have made substantial contributions. Ethology is the systematic study of...
Walther Birkmayer, one of the co-discoverers of the neuro chemical causes of Parkinson's disease and of its treatment by neurotransmitter-replacement ...
The Amine Oxidase Workshop was the brain child of Brian Callingham and Keith Tipton. The present book is the proceedings of the fourth in the series and in the past we have dedicated our meeting to individuals who have made significant fundamental contributions to the biochemistry, physiology and pharmacology of this interesting group of enzymes. The present meeting is not an exception because we have gathered here in Wtirzburg to honour an individual whose outstanding work on the autonomic pharmacology has span ned more than 30 years and whose contribution has made a vast impact in our...
The Amine Oxidase Workshop was the brain child of Brian Callingham and Keith Tipton. The present book is the proceedings of the fourth in the series a...
The role of the metals copper, zinc, magnesium, lead, manganese, mercury, lithium and aluminium in neuropsychiatric disease are well known and has been discussed on several occasions. Yet little attention has been paid to iron, the most abundant transitional metal in the body and the earth's crust. Iron plays a major role as a cofactor of numerous metabolic enzymes, it is important for DNA and protein synthesis, and has a crucial role in the oxygen carrying capacity of haemoglobin. Some of the most devastating diseases of systemic organs are associated with abnormal iron metabolism. Yet only...
The role of the metals copper, zinc, magnesium, lead, manganese, mercury, lithium and aluminium in neuropsychiatric disease are well known and has bee...
Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinson s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and...
Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of aff...
..". in der Tat umfassend, und den Herausgebern ist zu ihrem luckenlosen Konzept ... zu gratulieren ... sollte wunschen, dass das Handbuch nicht nur in der Handbibliothek der in Klinik und Praxis tatigen Neurologen und Psychiater sowie in der Forschung stehenden Pharmakologen, sondern auch in denen der ubrigen medizinischen Fachdisziplinen stehen moge, zumal gerade sie nicht selten diese Medikamentengruppe therapeutisch einsetzen." Zentralblatt Neurologie/Psychiatrie "Das Therapie-Handbuch Neuro-Psychopharmaka ist die deutschsprachige Alternative zu einem international bekannten Standardwerk...
..". in der Tat umfassend, und den Herausgebern ist zu ihrem luckenlosen Konzept ... zu gratulieren ... sollte wunschen, dass das Handbuch nicht nur i...
Die in sich abgeschlossenen Einzelbande des Werkes Neuro-Psychopharmaka stehen in ihrer Vollstandigkeit den in Klinik und Praxis tatigen Nervenarzten, Psychiatern und Neurologen sowie Grundlagenforschern als kompetentes Standardwerk der Psychopharmakologie zur Verfugung. Die Mitarbeit namhafter Experten burgt fur hochste wissenschaftliche Kompetenz unter Einbeziehung neuester klinischer und biochemisch-pharmakologischer Befunde. Intensive redaktionelle Bearbeitung sichert eine strikte Gliederung des Textes und einheitliche Abbildungen, wobei grosster Wert darauf gelegt wird, die komplexe...
Die in sich abgeschlossenen Einzelbande des Werkes Neuro-Psychopharmaka stehen in ihrer Vollstandigkeit den in Klinik und Praxis tatigen Nervenarzten,...
The aim of Early Markers in Parkinson's and Alzheimer's Diseases is to provide the reader with updated data on various approaches whose investigation and development could contribute to the discovery of early diag- nostic markers of these two degenerative diseases. Concerning Parkinson's disease, some of the topics dealt with in the book will help update the information previously reported in Early Diagnosis and Preventive Therapy in Parkinson's Disease. Concerning Alzheimer's disease, the scope and limitations of electrophysiological and brain imaging techniques...
The aim of Early Markers in Parkinson's and Alzheimer's Diseases is to provide the reader with updated data on various approaches whose...
Die in sich abgeschlossenen Einzelbande des Werkes Neuro-Psychopharmaka stehen in ihrer Vollstandigkeit den in Klinik und Praxis tatigen Nervenarzten, Psychiatern und Neurologen sowie Grundlagenforschern als kompetentes Standardwerk der Psychopharmakologie zur Verfugung. Die Mitarbeit namhafter Experten burgt fur hochste wissenschaftliche Kompetenz unter Einbeziehung neuester klinischer und biochemisch-pharmakologischer Befunde. Intensive redaktionelle Bearbeitung sichert eine strikte Gliederung des Textes und einheitliche Abbildungen, wobei grosster Wert darauf gelegt wird, die komplexe...
Die in sich abgeschlossenen Einzelbande des Werkes Neuro-Psychopharmaka stehen in ihrer Vollstandigkeit den in Klinik und Praxis tatigen Nervenarzten,...
This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block...
This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychia...
