Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Würzburg, Federal Republic of Germany,

ISBN-13: 9783211822395 / Angielski / Miękka / 1990 / 491 str.

Peter Riederer; Moussa B. H. Youdim

Opis

The Amine Oxidase Workshop was the brain child of Brian Callingham and Keith Tipton. The present book is the proceedings of the fourth in the series and in the past we have dedicated our meeting to individuals who have made significant fundamental contributions to the biochemistry, physiology and pharmacology of this interesting group of enzymes. The present meeting is not an exception because we have gathered here in Wtirzburg to honour an individual whose outstanding work on the autonomic pharmacology has span ned more than 30 years and whose contribution has made a vast impact in our understanding of the kinetic relationship between amine metabolism (that uptake and enzymatic inactivation) and adrenergic neurotransmission. We speak of course of Professor Ullrich Trendelenburg, or Ulli as he likes to be known. Like the amine oxidases, he has a unique place in Pharmacology. Professor Trendelenburg was born on the eve of the new year of 1922 in the city of Rostock in northern Germany, where his father was Professor of Pharmacology at the Faculty of Medicine of Rostock. His father accepted the offer to take over the corresponding chair in Freiburg im Breisgrau (in Southern Germany). As the youngest of four children, Ulli grew up mainly in the garden of the department, in the animal quarters and in the workshop. Of the various coworkers of his father, one he liked especially was Otto Krayer, the young pharmacologist.

Spis treści

The state of the art.- The interaction of transport mechanisms and intracellular enzymes in metabolizing systems.- In-vivo quantitative imaging of catecholaminergic nerve terminals in brain and peripheral organs using positron emission tomography (PET).- The mechanism of action of antidepressants revised.- Monoamine oxidase and its inhibitors.- The expression of human MAO-A and -B genes.- Molecular neuroanatomy of MAO-A and MAO-B.- Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-deprenyl.- Visualisation of brain monoamine oxidase B (MAO-B) in dementia of Alzheimer’s type by means of large cryosection autoradiography: a pilot study.- Immuno-fluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of monoamine oxidase A and monoamine oxidase B: a pilot study.- Effect of selective and reversible MAO inhibitors on dopamine outflow in rat striatum: a microdialysis study.- In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism in rat brain areas.- Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propy1-1-aminopentane and N-(2-propylpentyl)glycinamide as valproic acid precursors.- [3H] Harman labels selectively and with high affinity the active site of monoamine oxidase (EC 1.4.3.4) subtype A (MAOA) in rat, marmoset, and pig.- Inhibition of MAO by substituted tryptamine analogues.- Ring-substituted analogues of tranylcypromine as monoamine oxidase inhibitors.- Recent studies on the MAO inhibitor phenelzine and its possible metabolites.- Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates.- MAO activity, metabolism and anticonvulsant activity of milacemide in rats and mice.- Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat.- Effect of selegiline and desmethylselegiline on cortical electric activity in rats.- An enzymatic method for detecting MAO-A and MAO-B inhibitors in plasma and its application in studies with reversible MAO-A selective inhibitors.- Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity.- Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney.- Monoamine oxidase activity in blood platelets of migraine patients.- Monoamine oxidase inhibition by moclobemide and 2-aminoethyl carboxamide derivatives: mode of action and kinetic characteristics.- Does moclobemide stimulate melatonin synthesis as the other selective MAO-A inhibitors do?.- Efficacy and safety of moclobemide compared with imipramine in the treatment of major depressive disorder. Double-blind Multicenter Study, Austria.- Psychometric alterations in treatment with MAO-A-inhibitor moclobemide.- Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder.- Brofaromine (CGP 11 305 A): estimation of plasma concentrations by a biologic technique as compared to liquid chromatography.- A double-blind, placebo-controlled study of the tolerability and effects on platelet MAO-B activity of single oral doses of MDL 72.974A in normal volunteers.- MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time course.- Oxidative stress and autooxidation.- Monoamine oxidase and the bioactivation of MPTP and related neurotoxins: relevance to “DATATOP”.- Monoamine oxidase and oxidative stress at dopaminergic synapses.- The role of monoamine oxidase, iron-melanin interaction, and intracellular calcium in Parkinson’s disease.- Oxidation of the indole nucleus of 5-hydroxytryptamine and formation of dimers in the presence of peroxidase and H2O2.- Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms.- Effects of L-Deprenyl and Amantadine in an MPTP-Model of Parkinsonism.- Diamine oxidase — semicarbazide sensitive amine oxidase — polyamine oxidase.- Some aspects of the pharmacology of semicarbazide-sensitive amine oxidases.- Intestinal diamine oxidases and enteral-induced histaminosis: studies on three prognostic variables in an epidemiological model.- Methylamine oxidase from Arthrobacter P1 as a prototype of eukaryotic plasma amine oxidase and diamine oxidase.- Chronic ethanol feeding and diamine oxidase activity in rat brain and liver.- Amine oxidase activities in chemically-induced mammary cancer in the rat.- Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye.- Cultured preadipocytes produce a semicarbazide-sensitive amine oxidase (SSAO) activity.- Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells.- Amine oxidase activities in bovine lung.- Mucosal mono- and polyamine oxidase activities in digestive tract are distributed complementary to diamine oxidase.- Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide?.- Behaviour and properties of catechol-0-methyltransferase from human placenta.- Monoclonal antibodies recognizing both soluble and membrane bound catechol-0-methyl-transferase.- Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.- Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and 0-methylation of exogenous L-DOPA in the rat.- Effect of the new selective COMT inhibitor CGP 28 014 A on the formation of 3-0-methyldopa (30MD) in plasma of healthy subjects.- Uptake processes.- Oxidative deamination of noradrenaline in human blood vessels.- Modification of alpha-2 presynaptic receptor activity and catecholamine release following chronic MAO inhibition.- Biochemical characterization and purification of the neuronal sodium-dependent noradrenaline transporter.- The importance of plasma 3,4-dihydroxyphenylglycol (DOPEG) in analyses of the sympathetic nervous system in vivo.- The involvement of desipra-mine-sensitive processes in the extraction of various catecholamines from plasma in the anaesthetized rabbit.- Human Caki-1 cells are the first model for extraneuronal transport of noradrenaline (uptake2) which is based on a clonal cell line.- The synaptic noradrenaline concentration in humans as estimated from simultaneous measurements of plasma noradrenaline and dihydroxyphenylglycol (DOPEG).- Inhibition of MAO activity, 3H-imipramine binding, 3H-paroxetine binding and 3H-5-HT uptake by human cerebrospinal fluid.- ?2-Adrenoceptor responsivity in depression: effect of chronic treatment with moclobemide, a selective MAO-A-inhibitor, versus maprotiline.- Supersensitivity to catecholamines after inhibition of extraneuronal uptake (uptake2) or 0-methylation.- Sulfation.- Urinary dopamine sulfate: regulations and significance in neurological disorders.- Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson’s disease.