This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage...
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes ...
Rheumatoid arthritis (RA) is the most common and most severe form of i nflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have c hanged over the years, and have attempted to incorporate the most rece nt data. Although T cells represent an important component of the cell s that infiltrate the joint synovium, their contribution at a late sta ge of the disease remains a matter of debate.
Rheumatoid arthritis (RA) is the most common and most severe form of i nflammatory arthritis. The pathogenesis of RA has been the subject of intense r...
