T Cells in Arthritis

ISBN-13: 9783764358532 / Angielski / Twarda / 1998 / 236 str.

Wim B. Van Den Berg; Gary S. Firestein; Pierre Miossec

Opis

Rheumatoid arthritis (RA) is the most common and most severe form of i nflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have c hanged over the years, and have attempted to incorporate the most rece nt data. Although T cells represent an important component of the cell s that infiltrate the joint synovium, their contribution at a late sta ge of the disease remains a matter of debate.

Spis treści

T Cells as Secondary Players in Rheumatoid Arthritis.- T cell receptor rearrangements in arthritis.- T cell-independent joint destruction.- Role of T cells in arthritis: Lessons from animal models.- The Th1/Th2 cytokine balance in arthritis.- Interactions between T cell plasma membranes and monocytes.- Adhesion molecules in arthritis: Control of T cell migration into the synovium.- T cell reactivity to Epstein-Barr virus in rheumatoid arthritis.- T cell responses in reactive and Lyme arthritis.- T cell directed therapies and biologics.- T cells as primary players in rheumatoid arthritis.