This book provides the latest methodology to study cell signalling in cancer biology. It features protocols that can be easily adapted for the analysis of multiple members within a gene family taking into account the diversity of multigene families encoding or most signalling pathway intermediates.

Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling m- ecules in this context is a central component of cancer research. From the knowledge of such targets, investigators have been able to productively...