Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

• key interplay between transporters and enzymes in drug metabolism and drug interactions
• the integral role of pharmacogenetics in metabolism-based drug-drug interactions
• in vivo - in vitro correlations (reversible,...

The goal of this book is to provide a comprehensive view of the scientific bases on issues surrounding the importance of drug-enzyme and drug-transporter interactions and the quantitative predictions of clinically relevant transporter and enzyme based interactions. Although much progress has been made in predicting in vivo metabolic drug interactions based on in vitro studies, the quantitative prediction of clinically relevant transporter-and enzyme based drug interactions remains to be a challenge. The more complex metabolic drug interactions such as inductive, mechanism-based and allosteric...