This unique book presents a systematic review of the methods for the determination of binding constants of complex formation in solution. Material has been gathered which has been scattered throughout the literature of several separate fields. Offered here are methods from the areas of acid-based chemistry, metal- ion coordination compounds, hydrogen-bonding, charge-transfer complexation, hydrophobic interaction and protein-binding. The relevant thermodynamics, modelling, statistics and regression analysis, and interpretation of data are discussed, along with fresh discussions of random...

An accessible, single-source guide to the techniques, approximation methods and principles involved in studying drug stability and in making estimates of pharmaceutical product shelf-life. The book contains stability monographs of individual drugs, each reviewing cited data on kinetics of drug decomposition and methods for product stabilizations. Information on decomposiiton reactions, rate equations, pH-rate profiles, activation energies and formulation stability data are also featured.

Designed for pharmacy students

Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical laboratory applications. Designed to meet the needs of the contemporary curriculum in pharmacy schools, the text makes these connections clear, emphasizing specific applications to pharmaceutical systems including dosage forms and newer drug delivery systems.

Students and practitioners involved in drug discovery, drug delivery, and...