Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists

ISBN-13: 9780471879558 / Angielski / Twarda / 1986 / 864 str.

Kenneth A. Connors; Valentino J. Stella; Gordon L. Amidon

Opis

An accessible, single-source guide to the techniques, approximation methods and principles involved in studying drug stability and in making estimates of pharmaceutical product shelf-life. The book contains stability monographs of individual drugs, each reviewing cited data on kinetics of drug decomposition and methods for product stabilizations. Information on decomposiiton reactions, rate equations, pH-rate profiles, activation energies and formulation stability data are also featured.

Spis treści

PRINCIPLES.

Stability Calculations.

Interpretation of Kinetic Data.

Hydrolysis and Other Acyl Transfers.

Oxidation and Photolysis.

Solid–State Chemical Decompostion.

Strategy and Tactics of Stability Testing.

STABILITY MONOGRAPHS.

Appendixes.

Index.