Recent years have witnessed a resurgence of interest in the possible role of brain acetylcholine in neuropsychiatric disease. Research in this area has involved the renewed investigation of the cholinomimetics physostigmine and arecoline, and has been facilitated by the development of new potential cholinomimetics such as dimethylaminoethanol (Deanol) and choline chloride. Current investigators also have taken advantage of new approaches to neurochemical studies. Increasingly sensitive assay techniques such as gas chromatography/mass spectrometry have allowed investigators to measure low...