The earliest mention of a cell sheath enveloping the body of the neurons in sensory ganglia is probably the following description by Valentin: "Sowohl die Kugeln der Be- legungsformation 1 , als die Primitivfasem, werden von eigenthi. imlichen, sie isolirenden Scheiden umgeben, welche aile Stufen der Dicke von einer fast gar nicht mehr wahr- nehrnbaren Zartheit bis zu einer ziemlich bedeutenden Starke durchlaufen. Diese Hill- len sind aber immer zellgewebeartiger Natur" (1836, p 162). In some illustrations of the above mentioned paper the nuclei of the satellite cells adjacent to the surface...

During the second half of the 20th century, the introduction of a variety of new techniques greatly expanded our knowledge of the structure of nerve and neuroglial cells and of the organization of the nervous system at the cellular level. This new information has, however, generally been scattered throughout the literature, making it difficult for investigators to gain an overall vision of the discipline. The author has marshalled these scattered data to provide a systematic overview of the field placed within a historical context. He has correlated the major new findings with the classical...

2nd fully revised and updated edition

This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment.