Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and -DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether...

The use of intra-arterial therapy is not nearly as easy as the use of systemic intravenous therapy. The unique complications of intra-arterial therapy can be minimized by selecting the right drug delivery system and by judicious use of appropriate chemotherapeutic agents. Intra-arterial therapy should not be used by physicians who are unwilling to provide the commitment necessary. Experience and dedication are essential ingredients. Only careful clinical investigation can underwrite the future in this area. REFERENCES 1. Ensminger WD, Gyves JW: Regional cancer chemotherapy. Cancer Treat Rep...

Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and -DDP in combination with UV- induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether...