Intra-Arterial and Intracavitary Cancer Chemotherapy: Proceedings of the Conference on Intra-Arterial and Intracavitary Chemotheraphy, San Diego, Cali

ISBN-13: 9781461338451 / Angielski / Miękka / 2011 / 286 str.

Stephen B. Howell; Stephen B. Howell

Opis

The use of intra-arterial therapy is not nearly as easy as the use of systemic intravenous therapy. The unique complications of intra-arterial therapy can be minimized by selecting the right drug delivery system and by judicious use of appropriate chemotherapeutic agents. Intra-arterial therapy should not be used by physicians who are unwilling to provide the commitment necessary. Experience and dedication are essential ingredients. Only careful clinical investigation can underwrite the future in this area. REFERENCES 1. Ensminger WD, Gyves JW: Regional cancer chemotherapy. Cancer Treat Rep (68):101-115, 1984. 2. Clouse ME, Ahmed R, Ryan RB, Oberfield RA, McCaffrey JA: Complications of long-term transbrachial hepatic arterial infusion chemotherapy. Am J Roentgenol (129):799-803, 1977. 3. Niederhuber JE, Ensminger WD, Gyves JW, Thrall J, Walker S, Cozzi E: Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer (53):1336-1343, 1984. 4. Lokich J, Ensminger W: Ambulatory pump infusion devices for hepatic artery infusion. Sem Onc (10):183-190, 1983.

Spis treści

Session I: Pharmacology and Techniques.- Pharmacokinetic Rationale for Intra-arterial Therapy.- Technical Aspects of Arterial Access and Constant Infusion.- Management, Complications, and Evaluation of Intra-arterial Infusions.- Pharmacokinetic Rationale for Intracavitary Therapy.- Surgical Principles of Intraperitoneal Access and Therapy.- Medical Principles of Intraperitoneal and Intrapleural Chemotherapy.- Session II: Clinical Trials of Intra-arterial Therapy.- Intra-arterial Therapy of Hepatic Metastases.- Intra-arterial vs Intravenous FUDR for Colorectal Cancer Metastatic to the Liver: A Northern California Oncology Group Study.- Randomized Study of Intrahepatic vs. Systemic Infusion of Fluorodeoxyuridine in Patients with Liver Metastases from Colorectal Carcinoma (Preliminary Results).- The Rationale and Methodology for Intra-arterial Chemotherapy with BCNU as Treatment for Glioblastoma.- Intra-arterial Cis-Platinum in Advanced Solid Tumors.- Hepatic Arterial Infusion of Floxuridine, Adriamycin and Mitomycin C for Primary Liver Neoplasms.- Intra-arterial Adriamycin Radiation Therapy, and Surgical Excision for Extremity, Skeletal and Soft Tissue Sarcomas.- Session III; Clinical Trials of Intracavitary Chemotherapy.- Phase I Trials and Pharmacokinetic Studies of Intraperitoneal Cisplatin, Melphalan, Methotrexate and Cytarabine.- A Phase I Trial of Intracavitary Doxorubicin (Adriamycin) Alternating with Cisplatin.- Clinical Pharmacology of Intraperitoneal (IP) Bolus Mitomycin C and Continuous IP Infusion 5-Fluorouracil.- Intraperitoneal Adriamycin and 5-Fluorouracil in Ovarian Carcinoma.- Combination Cisplatin Based Intracavitary Chemotherapy.- Intravesicle Doxorubicin for Prophylaxis in the Management of Recurrent Superficial Bladder Carcinoma — An Update.- Session IV: Current Research on Novel Approaches.- Degradable Starch Microspheres.- Magnetic Drug-Containing Microspheres.- Polymer Immobilized Doxorubicin as a Regional Therapeutic Agent.- The Use of Radiolabeled Antibody in Cancer Chemotherapy.- Intracavitary Hyperthermia and Intra-arterial Chemotherapy.- Combination Hyperthermia and Intra-arterial Chemotherapy.