This book examines the rapidly evolving microsystem technology that promises to unravel a wide range of applications in biology, gene therapy, molecular medicine, and forensics. These applications will have crucial bearing on future work in the diagnosis of disease and combinatorial chemistry. In addition, the work covers application strategies, theoretical aspects, protocols, and patents.

A Safety Considerations Genomic sequencing involves a number of hazardous steps, such as high current, high voltage, radioactive and highly toxic chemicals. It is, therefore, absolutelyessen- tial that the instructions of equipment manufacturers be followed and that particular attention is paid to the local and federal safety regulations. INTRODUCTION 9 B Introduction During the cloning of genomic DNA many of its characteristics are perma- nently lost. It was therefore necessary to develop a new technique that would give us a closer look at a gene in its normal environment. The powerful...