The prediction of the three-dimensional structure of a protein from it s amino acid sequence is a problem faced by an increasing number of bi ological scientists. This book provides a practical guide to making th ese predictions by reviewing strategies of different computer modeling algorithms and highlighting the degree of confidence attributed to th em. Also in the volume are descriptions of the following: the principl es of protein folding; sequence homology and motif searches; predictio n of secondary structure; homology modeling; modeling of antibody comb ining sites; tertiary fold...