This work describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process, including preformulation, formulation, process study and optimization, scale-up, robust processes and formulation development. The authors show how to overcome pharmaceutical, technological and economic constraints on experiment design.

Young peoples' disaffection with mathematics is a problem since it is a key factor in disengagement, lack of participation, progression and attainment. Large numbers of young people are becoming effectively 'lost' to mathematics with the result that too many young people are leaving education without the competence in mathematics that they require for successful citizenship. Disaffection with School Mathematics reports on an investigation into disaffection with school mathematics undertaken by the author. Too little is known about both the nature and the causes of disaffection, and in this...

Young peoples' disaffection with mathematics is a problem since it is a key factor in disengagement, lack of participation, progression and attainment. Large numbers of young people are becoming effectively 'lost' to mathematics with the result that too many young people are leaving education without the competence in mathematics that they require for successful citizenship. Disaffection with School Mathematics reports on an investigation into disaffection with school mathematics undertaken by the author. Too little is known about both the nature and the causes of disaffection, and in this...