Pharmaceutical Experimental Design

ISBN-13: 9780824798604 / Angielski / Twarda / 1998 / 512 str.

Gareth Lewis; Didier Mathieu; Roger Phan-Tan-Luu

Opis

This work describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process, including preformulation, formulation, process study and optimization, scale-up, robust processes and formulation development. The authors show how to overcome pharmaceutical, technological and economic constraints on experiment design.

Spis treści

1. Overview 2. Screening 3. Factor Influence Studies 4. Statistical and Mathematical Tools 5. Response Surface Methodology 6. Optimization 7. Variability and Quality 8. Exchange Algorithms 9. Mixtures 10. Mixtures in a Constrained Region of Interest

O autorze

Lewis, Gareth A.; Mathieu, Didier; Phan-Tan-Luu, Roger