"Bioactive Heterocycles III" provides readers with a comprehensive overview of the most recent breakthroughs in the ?eld of heterocycles. This volume contains 8 chapters written by experts in their respective ?elds from all over the world. The chapters summarize years of extensive research in each area, andprovideinsightinthenewthemesofnaturalproductresearch.Manyofthe contributors illustrate their laboratory experiences. It's obvious that readers will gain exciting and essential information fromthe volume. In the ?rst chapter, Kayser et al. describe the chemistry, biosynthesis and biological...

This volume contains nine more contributions from expert researchers of the ?eld, providing readers with in depth and current research results regarding therespective topics. In the ?rst chapter, Flemming et al. review the chemistry, biosynthesis, metabolism and biological activities of tetrahydrocannabinol and its deri- tives. Hansch and Verma contribute to the quantitative structure-activity re- tionship (QSAR) analysis of heterocyclic topoisomerase I and II inhibitors. These inhibitors, knowntoinhibit either enzyme, actasantitumoragentsand are currently used in chemotherapy and in...

Aromaticity is a notion that appeared in the mid-nineteenth century to differentiate between unsaturated hydrocarbons and formally unsaturated benzene 1-3]. At the end of the nineteenth century it seemed that cyclicity was a necessary condition for differentiation between the two, but at the beginning of the twentieth century it turned out that the above assumption was not correct because cyclooctatetraene exhibited typical properties known for polyenes 4]. The essential property of b- zene-like compounds, often identified with aromatic compounds, was low react- ity. Hence thermodynamic...

The series "Topics in Heterocyclic Chemistry" will present critical reviews on "Heterocyclic Compounds" within topic related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of...

Fruits and vegetables contain abundant nutraceuticals or phytochemicals such as carbohydrates, proteins, lipids, vitamins, enzymes, dietary ?bers, min- als, antioxidants, ?avonoids, and anthocyanins and other diverse components including trace chemicals. Interestingly, the ?avonoids and anthocyanins in phytochemicals could be signi?cantly associated with reductions of risk of cardiovascular disease, macular degeneration, and improvements and prev- tions of many other diseases. Actually, ?avonoids and anthocyanins in plants could play a very important role in our daily health. Our ancestors...

Explanation of the structure-property relationship of a given molecule is generally simple because the characteristics of the atomic groups and chemical bonds and the effects emerging from their interaction have long been known, both from theore- cal studies and numerous experimental results. In contrast, it is often difficult to analyze, estimate, and account for the structure-properties relationship in sup- molecules. The characteristics of supramolecules are governed both by the nature of the constituent molecules and by their configuration while the characteristics of the constituent...

Contents: S. Sasaki: Heterophenes Carrying Phosphorus Functional Groups as Key Structures.- D.D. Enchev: Synthesis and Biological Activity of 2,5-Dihydro-1,2-Oxaphosphole-2-Oxide Derivatives.- D. Gudat: Recent Developments in the Chemistry of N -Heterocyclic Phosphines.- J. Drabowicz ∙ D. Krasowska ∙ A. Lopusiński ∙T.S.A. Heugebaert ∙ C.V. Stevens: Selected Five-Membered Phosphorus Heterocycles Containing a Stereogenic Phosphorus.- G. Keglevich: 1-(2,4,6-Trialkylphenyl)-1 H -Phospholes with a Flattened P-Pyramid: Synthesis and Reactivity.- N. Gupta: Recent...

Geraldine Masson, Luc Neuville ? Carine Bughin ? Aude Fayol ? Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Muller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ? Eelco Ruijter ? Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ? Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ? Jalpa C. Trivedi ? Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini...