This book is divided into 5 Chapters in which Chapter 1 contains introduction on anticancer tyrosine kinase inhibitors, Chapter 2 contains an overview of drug design and quantitative structure-activity relationship, Chapter 3 contains literature review, Chapter 4 contains plan of work and methodology and finally Chapter 5 contains work done and discusses in detail the results obtained. A quantitative structure-activity relationship (QSAR) study has been made on some series of anticancer tyrosine kinase inhibitors, namely, a series of aminopropyl tetrahydroindole-based indolin-2-ones, a series...

Hypertension is one of the cardiovascular diseases which is most common throughout the world. It is generally defined as an elevation of systolic and/or diastolic arterial blood pressure, which is 120/80 mm Hg in normal situation. A value of 140/90 mm is generally accepted as the upper limit of normotension. Hypertension with certain risk factors such as hypercholes- terolemia, diabetes, smoking and a family history of vascular disease pre- disposes to arteriosclerosis and consequent cardiovascular morbidity and mortality. The treatment of hypertension leads to reduced risk of hyperten- sive...