Y.A. Berlin, I.V. Kurnikow, D. Beratan, M.A. Ratner, A.L. Burin: DNA Electron Transfer Processes: Some Theoretical Notions; N. Rosch, A.A. Voityuk: Quantum Chemical Calculation of Donor-Acceptor Coupling for Charge Transfer in DNA; E. Conwell: Polarons and Transport in DNA; Z. Cai, M.D.

Table of contents C. Heise, F.F. Bier: Immobilization of DNA on Microarrays.- I. Palchetti; M. Mascini: Electrochemical Adsorption Technique for Immobilisation of Single-Stranded Oligonucleotides onto Carbon Screen-Printed Electrodes.- Q. Du, O. Larsson, H. Swerdlow, Z. Liang: DNA Immobilization: Silanized Nucleic Acids and Nanoprinting.- C.L. Smith, J.S. Milea, G.H. Nguyen: Immobilization of Nucleic Acids Using the Biotin-Strept(avidin) Systems.- K. Yokoyama, S. Taira: Self-Assembly DNA-Conjugated Polymer for DNA Immobilization on Chip.- C.A. Marquette, L.J. Blum: Beads Arraying and Beads...

This book presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The book is still valid and useful after 5 or 10 years. More information as well as the electronic version of the whole content is available at: springerlink.com. The book will interest scientists and practitioners in the mentioned fields and in industry.

Keeping up with the advances in modern heterocyclic chemistry is essential for many of our colleagues in academia and industry. It is the aim of this series on "Stereoselective Heterocyclic Synthesis" to assist the chemical community in this respect by presenting a selection of exciting recent developments. As it was for the first two volumes (1997), the stereoselective synthesis of - or with the aid of - heterocycles is the common motif for all the chapters in this third volume. I am very glad that again leading researchers in this area have contrib- ed highly stimulating accounts with...

With the present issue of Topics in Current Chemistry, the fourth and final volume concluding the mini-series on dendrimer chemistry has appeared. With a focus on the interdisciplinary bridges to neighboring fields, the contributions to this volume focus on coordination, catalysis and self-assembly, nicely balanced by a synthesis-based article on dendritic oligoethers.

Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1-2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most...

Fluorine is unique in that it is possible to replace hydrogen by fluorine either singly or multiply, in an organic molecule and, in so-doing create a potentially infinite extension to organic chemistry that is entirely synthetic. The excitement of the chemistry of these systems stems from the unique reactions that ensue and the special-effects that introduction of fluorine impart. Indeed, these effects are now exploited in a remarkable array of applications across the whole of the chemical, pharmaceutical, and plant-protection industries, although this is not widely appreciated. In this book,...

The second volume on dendrimers is again written by pioneers in the field. Their contributions illuminate the aspects of dendrimers mentioned in the subtitle, and also touch on areas beyond chemistry, namely material sciences as well as biological, medicinal, analytical, and nano aspects.

There exists a large literature on the spectroscopic properties of copper(II) com- 9 pounds. This is due to the simplicity of the d electron configuration, the wide variety of stereochemistries that copper(II) compounds can adopt, and the f- xional geometric behavior that they sometimes exhibit 1]. The electronic and geometric properties of a molecule are inexorably linked and this is especially true with six-coordinate copper(II) compounds which are subject to a Jahn-T- ler effect.However, the spectral-structural correlations that are sometimes d- wn must often be viewed with caution as the...

Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and...