Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the...
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling com...
This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study.
Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane,...
This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as th...
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few.
The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also...
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dyna...
This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.
Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well...
This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.
This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established.
The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes....
This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the so...
Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases.
The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment...
Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, s...
This book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of ageing as seen in clinical practice.
To this end, the reader learns about the historical development and progression of clinical ageing research. All chapters address the biochemistry or cell biology of various ageing events (to the extent that the data are available) and work their way to the clinical understanding we have of ageing. The focus of this volume is on how dietary restriction, virus infection and chronic inflammation affect the...
This book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of age...
Virus-infected Cells is a comprehensive and technical exploration of the intricate interactions between viruses and host cells. This book delves into the molecular and cellular aspects of viral infections, providing a wealth of knowledge about various viruses and their effects on cellular mechanisms.
The first part of the book covers general/technical aspects, introducing the reader to the field of virology and providing an overview of the techniques used to study virus-infected cells. It covers topics such as the visualisation of virus-infected cells by cryo-electron tomography...
Virus-infected Cells is a comprehensive and technical exploration of the intricate interactions between viruses and host cells. This book delves in...
This volume in the Subcellular Biochemistry (SCBI) series is a continuation of several previous volumes devoted to the structural and functional study of protein complexes. The expanding nature of this field of study, derived mainly from X-ray crystallography and electron cryomicroscopy, justifies the continuing expansion of coverage in an almost encyclopaedic manner within the SCBI series.
Experienced and active researchers in the field shed light on the biology of protein complexes involved in important cellular functions from different perspectives, such as AcrAB-TolC, and CST....
This volume in the Subcellular Biochemistry (SCBI) series is a continuation of several previous volumes devoted to the structural and functional st...
This book provides an up-to-date overview of key areas of ageing research with a special focus on anti-ageing intervention strategies, which are currently very much at the forefront of ageing studies.
The volume discusses how dietary restriction, supplements or exercise affect the ageing process. Other intervention strategies reviewed are: chaperone activators, telomerase activation, hormetics, senolytics, NAD boosting, geroprotectors, stem cell therapies, resveratrol and melatonin, to just name a few.
This book follows on from Parts I-IV of Biochemistry and Cell...
This book provides an up-to-date overview of key areas of ageing research with a special focus on anti-ageing intervention strategies, which are cu...
