This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provides the first comprehensive coverage of the topic of interval-censored data and complements the books on right-censored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an up-to-date reference for people who are conducting research on the analysis of interval-censored failure time data as well as for those who need to analyze...
This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provide...
Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community.
This book provides an introduction to some of these new methods. The main biological topics treated include sequence...
Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated t...
'Which test should I apply?' During the many years of working with ecologists, biologists and other environmental scientists, this is probably the question that the authors of this book hear the most often. The answer is always the same and along the lines of 'What are your underlying questions?', 'What do you want to show?'. The answers to these questions provide the starting point for a detailed discussion on the ecological background and purpose of the study. This then gives the basis for deciding on the most appropriate analytical approach. Therefore, a better start- ing point for an...
'Which test should I apply?' During the many years of working with ecologists, biologists and other environmental scientists, this is probably the que...
Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of...
Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic...
Recurrent event data arise in diverse fields such as medicine, public health, insurance, social science, economics, manufacturing and reliability. The purpose of this book is to present models and statistical methods for the analysis of recurrent event data. No single comprehensive treatment of these areas currently exists. The authors provide broad but detailed coverage of the major approaches to analysis, while also emphasizing the modeling assumptions that they are based on. Thus, they consider important models such as Poisson and renewal processes, with extensions to incorporate...
Recurrent event data arise in diverse fields such as medicine, public health, insurance, social science, economics, manufacturing and reliability. ...
Clustered survival data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public health and demography. Frailty models provide a powerful tool to analyse clustered survival data. In contrast to the large number of research publications on frailty models, relatively few statistical software packages contain frailty models.
It is demanding for statistical practitioners and graduate students to grasp a good knowledge on frailty models from the existing literature. This book provides an in-depth discussion and explanation of...
Clustered survival data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public healt...
I write this foreword for two reasons: first, to acknowledge the gratitude of our court system to scientists willing to lend their talents to forensic tasks, and of myself, in particular, for the pathbreaking work of Eric Stallard, Kenneth G. Manton, and Joel E. Cohen in the Manville Asbestos Case; and second, because their work suggests both great strength and utility in their statisti- cally based design and its limitations in predicting events strongly affected by political and social choices that are difficult to foretell as well as by de- mographic and epidemiologic factors that can be...
I write this foreword for two reasons: first, to acknowledge the gratitude of our court system to scientists willing to lend their talents to forensic...
During the past decade, geneticists have cloned scores of Mendelian disease genes and constructed a rough draft of the entire human genome. The unprecedented insights into human disease and evolution offered by mapping, cloning, and sequencing will transform medicine and agriculture. This revolution depends vitally on the contributions of applied mathematicians, statisticians, and computer scientists. Mathematical and Statistical Methods for Genetic Analysis is written to equip students in the mathematical sciences to understand and model the epidemiological and experimental data encountered...
During the past decade, geneticists have cloned scores of Mendelian disease genes and constructed a rough draft of the entire human genome. The unprec...
Thedevelopmentoftechnologiesforhigh-throughputmeasurementofgene expression in biological system is providing powerful new tools for inv- tigating the transcriptome on a genomic scale, and across diverse biol- ical systems and experimental designs. This technological transformation is generating an increasing demand for data analysis in biological inv- tigations of gene expression. This book focuses on data analysis of gene expression microarrays. The goal is to provide guidance to practitioners in deciding which statistical approaches and packages may be indicated for their projects, in...
Thedevelopmentoftechnologiesforhigh-throughputmeasurementofgene expression in biological system is providing powerful new tools for inv- tigating the ...
This is a book for statistical practitioners, particularly those who design and analyze studies for survival and event history data. Its goal is to extend the toolkit beyond the basic triad provided by most statistical packages: the Kaplan-Meier estimator, log-rank test, and Cox regression model. Building on recent developments motivated by counting process and martingale theory, it shows the reader how to extend the Cox model to analyse multiple/correlated event data using marginal and random effects (frailty) models. It covers the use of residuals and diagnostic plots to identify...
This is a book for statistical practitioners, particularly those who design and analyze studies for survival and event history data. Its goal is to ex...
