This text deals with parametric and nonparametric density estimation from the maximum (penalized) likelihood point of view, including estimation under constraints such as unimodality and log-concavity. It is intended for graduate students in statistics, applied mathematics, and operations research, as well as for researchers and practitioners in the field. The focal points are existence and uniqueness of the estimators, almost sure convergence rates for the L1 error, and data-driven smoothing parameter selection methods, including their practical performance. The reader will gain insight into...

Survival analysis arises in many fields of study including medicine, biology, engineering, public health, epidemiology, and economics. This book provides a comprehensive treatment of Bayesian survival analysis. Several topics are addressed, including parametric models, semiparametric models based on prior processes, proportional and non-proportional hazards models, frailty models, cure rate models, model selection and comparison, joint models for longitudinal and survival data, models with time varying covariates, missing covariate data, design and monitoring of clinical trials, accelerated...

This volume deals primarily with the classical question of how to draw conclusions about the population mean of a variable, given a sample with observations on that variable. Another classical question is how to use prior knowledge of an economic or definitional relationship between the popu- lation means of several variables, provided that the variables are observed in a sample. The present volume is a compilation of two discussion papers and some additional notes on these two basic questions. The discussion papers and notes were prepared for a 15-hour course at Statistics Nether- lands in...

In the past 15 to 20 years, the computer has become a popular tool for exploring the relationship between a measured response and factors thought to affect the response. In many cases, scientific theories exist that implicitly relate the response to the factors by means of systems of mathematical equations. There also exist numerical methods for accurately solving such equations and appropriate computer hardware and software to implement these methods. In many engineering applications, for example, the relationship is described by a dynamical system and the numerical method is a finite...

The regression estimation problem has a long history. Already in 1632 Galileo Galilei used a procedure which can be interpreted as ?tting a linear relationship to contaminated observed data. Such ?tting of a line through a cloud of points is the classical linear regression problem. A solution of this problem is provided by the famous principle of least squares, which was discovered independently by A. M. Legendre and C. F. Gauss and published in 1805 and 1809, respectively. The principle of least squares can also be applied to construct nonparametric regression estimates, where one does not...

Bayesian nonparametrics has grown tremendously in the last three decades, especially in the last few years. This book is the first systematic treatment of Bayesian nonparametric methods and the theory behind them. While the book is of special interest to Bayesians, it will also appeal to statisticians in general because Bayesian nonparametrics offers a whole continuous spectrum of robust alternatives to purely parametric and purely nonparametric methods of classical statistics. The book is primarily aimed at graduate students and can be used as the text for a graduate course in Bayesian...

During the last decades, there has been an explosion in computation and information technology. This development comes with an expansion of complex observational studies and clinical trials in a variety of fields such as medicine, biology, epidemiology, sociology, and economics among many others, which involve collection of large amounts of data on subjects or organisms over time. The goal of such studies can be formulated as estimation of a finite dimensional parameter of the population distribution corresponding to the observed time-dependent process. Such estimation problems arise in...

Directly oriented towards real practical application, this book develops both the basic theoretical framework of extreme value models and the statistical inferential techniques for using these models in practice. Intended for statisticians and non-statisticians alike, the theoretical treatment is elementary, with heuristics often replacing detailed mathematical proof. Most aspects of extreme modeling techniques are covered, including historical techniques (still widely used) and contemporary techniques based on point process models. A wide range of worked examples, using genuine datasets,...

In many statistical applications the scientists have to analyze the occurrence of observed clusters of events in time or space. The scientists are especially interested to determine whether an observed cluster of events has occurred by chance if it is assumed that the events are distributed independently and uniformly over time or space. Applications of scan statistics have been recorded in many areas of science and technology including: geology, geography, medicine, minefield detection, molecular biology, photography, quality control and reliability theory and radio-optics.