The purpose of this monograph is to develop a very general approach to the algebra- ization of sententiallogics, to show its results on a number of particular logics, and to relate it to other existing approaches, namely to those based on logical matrices and the equational consequence developed by Blok, Czelakowski, Pigozzi and others. The main distinctive feature of our approachlies in the mathematical objects used as models of a sententiallogic: We use abstract logics, while the dassical approaches use logical matrices. Using models with more structure allows us to reflect in them the...

Focuses on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

Neuroscience has paid only little attention to decision-making for many years. Although no field of science has cohered around this topic, a variety of researchers in different areas of neuroscience ranging from cellular physiology to neuropsychology and computational neuroscience have been engaged in working on this issue. Thus, the time seemed to be ripe to bring these researchers together and discuss the state of the art of the neurobiology of decision-making in a broad forum. This book is a collection of contributions presented at that forum in Paris in October 1994 organized by the...

This volume is based on a meeting of the Fondation IPSEN, held in Paris on Sep tember 18, 1995 to address the main issues of nervous system stem cells biology. Cell replacement in the adult mammals is not unusual outside the nervous sys tem. In fact, the nervous system is unique in lacking the ability to replace cells, following damage. Most neurons, in the adult central nervous system are termin of the organism and are not replaced ally differentiated, exist through the life when they die. There are, however, regions of the postnatal brain that continue to produce new neurons, but the fate...

In the past few years, the Fondation IPSEN has been increasing its activity in the neurosciences, especially by supporting researchers working on Alzheimer's disease. This interest in the subject is demonstrated by a prize and a fellowship, which have been awarded each year since 1985, a monthly newsletter, and a series of Colloques Medecine et Recherche and their proceedings which are distributed world-wide. Since 1990, our effort in the field of neuroscience has been considerably enhanced. A new series of Colloques Medecine et Recherche has been devoted to this topic. Like the meetings on...

Gene transfer technology is a powerful tool for increasing our understandingof brain functions. It is also the basis of gene therapy, which is now technically possible for the correction of many human diseases, including several disorders of the nervous (and muscular) system such as Alzheimer's disease, Parkinson's disease, and dystrophy. This volume, which contains the proceedings of a symposium of the Fondation Ipsen, provides a unique view of the state of the art on different transgenes, vectors, target cells, and clinical applications related to the nervous system.

The prefrontal cortex is particularly challenging as it has undergone great expansion during phylogenetic development and because it plays a crucial role in regulating most complex behaviors. Progress in research techniques in animals and in the development of non-invasive brain imaging approaches in humans have allowed resurgence of interest in the prefrontal cortex. To shed light on the rapidly accumulating information on motor and cognitive functions of the prefrontal cortex the Fondation IPSEN organized a symposium. This volume contains the proceedings of this meeting giving the most...

Temporal coding in the brain documents a revolution now occurring in the neurosciences. How does parallel processing of information bind together the complex nature of the outer and our inner worlds? Do intrinsic oscillations and transient cooperative states of neurons represent the physiological basis of cognitive and motor functions of the brain? Some answers to these challenging issues are provided in this book by leading world experts of brain function. A common denominator of the works presented in this volume is the nature and mechanisms of neuronal cooperation in the temporal domain....

ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional levelof?netuningofthegenomeandhowgenesareusedagainandagainin differentcombinationstogeneratethecomplexitythatunderliesforinstancethe brain. SincetheinitialstudiesperformedinC. elegans, wegavegoneafarwayto begintounderstandhowmicroRNApathwayscanhaveanimpactonhealthand diseaseinhuman. AlthoughmicroRNAsareabundantlyexpressedinthebrain, relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe nervous system. Nevertheless, we knowalready that microRNA pathways play majorrolesintheproliferation, differentiation,...