Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. The aim of this second edition is to act as a complement to the first by describing and updating the standard models that are most utilized for specific disease areas. In addition, this 2nd edition includes new models exploring emerging areas of inflammation research.
It provides detailed descriptions of the...
Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a descripti...
In Vivo Models of Inflammation (Volume 1 and Volume 2) provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research.
The format is designed with the laboratory in mind: Both volumes provide...
In Vivo Models of Inflammation (Volume 1 and Volume 2) provides the biomedical researcher in both the pharmaceutical industry and academia with a d...
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also...
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecule...
Cardiomyopathy is one of the most frequent causes of heart failure, and a leading entity of cardiac transplantation in the era of modern heart failure regimens. This volume focuses on major advances in inflammatory cardiomyopathy (DCMi) during the past 10 years. The book is divided up into the following sections: 1. Myocarditis and inflammatory cardiomyopathy clinical management, epidemiology and prognosis; 2. Animal Models of myocarditis autoimmunity and viral infection; therapeutic interventions; 3. Alterations of the immune system in human viral and inflammatory cardiomyopathy; 4....
Cardiomyopathy is one of the most frequent causes of heart failure, and a leading entity of cardiac transplantation in the era of modern heart failure...
Matrix metalloproteinases (MMPs) are proteolytic enzymes believed to be involved in many physiological and pathological processes associated with inflammatory reactions. MMP synthesis and functions are regulated by three major mechanisms including transcriptional activation, post-transcriptional processing, and control of activity by tissue inhibitors of metalloproteinases (TIMPs). Many cell types have been identified as producers of MMPs and TIMPs in a context of inflammatory processes. MMPs are involved in numerous inflammatory diseases, including respiratory, cardiovascular and central...
Matrix metalloproteinases (MMPs) are proteolytic enzymes believed to be involved in many physiological and pathological processes associated with i...
It is now accepted that T cell activation by an antigen-presenting cell requires the organization of a supramolecular structure the immune synapse. This structure, with different types of molecules spatially segregated, is involved in the delivery of quantitative and qualitative signals critical for T cell activation, and therefore in controlling the nature of the immune response. This volume discusses the progress in manipulating components of the immune synapse as a strategy to regulate the immune response in immune pathology, such as transplantation, autoimmunity and allergy. Donnadieu...
It is now accepted that T cell activation by an antigen-presenting cell requires the organization of a supramolecular structure the immune synapse. Th...
The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyse or to critically review microarray experiments related to inflammation research.
So far, non of the published books covers all aspects which need to be taken into account when planning and performing a microrray experiment in inflammation research. Normally,...
The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to...
Angiogenesis is an essential component of inflammation and its resolution. This volume provides up-to-date information on the latest developments in the pathology, mechanisms and therapy of angiogenesis dependent inflammatory disease. Recent years have seen large advances in angiogenesis research, especially in oncology. Traditionally mechanisms in inflammation angiogenesis were inferred from tumour angiogenesis, however recent research has matured highlighting the similarities and dissimilarities between these processes. This volume relates the lessons learned from tumour biology applied...
Angiogenesis is an essential component of inflammation and its resolution. This volume provides up-to-date information on the latest developments i...
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a...
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and...
Recent developments in the field of occupational asthma research and clinical practice are the topic of this volume. The contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults is clearly described in an overview of the most recent epidemiological data from both general population and industry based studies. Emphasis is put on powerful approaches like the use of apprentices studies, which include young individuals, naive with regard to occupational exposures. Diagnostic criteria for work related and work aggravated asthma are introduced...
Recent developments in the field of occupational asthma research and clinical practice are the topic of this volume. The contribution of occupation...
