This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies, which are tied together through their frequent fusion and coevolution, have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein...
This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, ev...
Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.
Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a uniqu...
This book presents applications of bioinformatics tools that experimental research scientists use in "daily practice." Its interdisciplinary approach combines computational and experimental methods to solve scientific problems. The book begins with reviews of computational methods for protein sequence-structure-function analysis, followed by methods that use experimental data obtained in the laboratory to improve functional predictions.
This book presents applications of bioinformatics tools that experimental research scientists use in "daily practice." Its interdisciplinary approa...
In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs and the variations encountered in different organisms.
In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. This v...
This book constitutes the refereed proceedings of the Third European Conference on Computational Learning Theory, EuroCOLT'97, held in Jerusalem, Israel, in March 1997. The book presents 25 revised full papers carefully selected from a total of 36 high-quality submissions. The volume spans the whole spectrum of computational learning theory, with a certain emphasis on mathematical models of machine learning. Among the topics addressed are machine learning, neural nets, statistics, inductive inference, computational complexity, information theory, and theoretical physics.
This book constitutes the refereed proceedings of the Third European Conference on Computational Learning Theory, EuroCOLT'97, held in Jerusalem, Isra...
Editing a book on editing has a certain tongue in cheek connotation to it, and I must admit that I was not aware what the job truly entailed when the project started. However, over the many months that it took to complete the book, it was interesting to realize that indeed printing-type editing and biological editing have many matching characteristics. Therefore, the quote by the well-known ? lm editor Verna Fields (1918 1982), I wish the word editing had never been invented, editing implies correcting, and it s not, can function as a motto for the book: the various biological phenomena that...
Editing a book on editing has a certain tongue in cheek connotation to it, and I must admit that I was not aware what the job truly entailed when the ...
This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.
This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organ...
It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer s (amyloid plaques) and Parkinson s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to...
It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for A...
This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies, which are tied together through their frequent fusion and coevolution, have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein...
This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, ev...
Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the site-specific replacement of any amino acid in a protein with one of the other nineteen amino acids, it ushered in the new era of "Protein Engineering." The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins. The chapters included in this book...
Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the sit...
