Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientrsts and is written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the wrdest range of s- disciplines. Collecting these general techniques together in a single volume strikes us not only as...
Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, a...
Serendipitous discovery has played an important role m the identification of physiological mechanisms in central and peri- eral neurotransmission. In many cases, the subsequent followup of these discoveries has been substantially aided by previouslyiden- fied natural substances that interfered with these mechanisms. The site of neuromuscular blockade produced by curare extracts, for example, was shown in the 1850s by Claude Bernard, and Sir Henry H. Dale m 1906 discovered the reversal of the pressor effects of adrenal extracts by ergot alkaloids. These findings were the first clues that led...
Serendipitous discovery has played an important role m the identification of physiological mechanisms in central and peri- eral neurotransmission. In ...
A superb collection of time-tested, key techniques for investigating nervous system function, as well as the actions of drugs on the nervous system. The methods range from authoritative treatment of such well-established techniques as recording electrical activity in the brain, to practical coverage of state-of-the-art methods, including neural transplantation and antisense technology. The techniques described are particularly suitable for studying the mechanisms of action of psychotropic drugs and drugs of abuse, as well as the etiology and pharmacotherapy of neuropsychiatric diseases and...
A superb collection of time-tested, key techniques for investigating nervous system function, as well as the actions of drugs on the nervous system. T...
This is a comprehensive collection of the electrophysiological recording techniques, methods, and protocols used in studying the measurements of the electrical activity of neurons (particularly their action potential activity) in both animal and humans models.
This is a comprehensive collection of the electrophysiological recording techniques, methods, and protocols used in studying the measurements of th...
Efforts to measure neurotransmitters and related s- cies in living brain tissue by faradic electrochemistry began in earnest in the early 1970s. During the ensuing years, s- eral monographs and various symposia on the subject have appeared. The present volume of Neuromethods, Voltammetric Methods in Brain Systems, can be considered different from previous offerings in several respects. The methodology of in vivo electrochemistry has now reached a stable level of maturity. It is no longer necessary to convince interested re- ers that the techniques can measure, with specified degrees of...
Efforts to measure neurotransmitters and related s- cies in living brain tissue by faradic electrochemistry began in earnest in the early 1970s. Durin...
As fMRI technology has provided invaluable insights into the mechanisms through which the human brain works in healthy individuals and in patients with different neurological and psychiatric conditions, the study of brain function and even the monitoring of the effects of treatment have become more effective and efficient. In fMRI Techniques and Protocols, an international assemblage of renowned scientists and physicians provide the background needed to plan and design new studies in order to advance our knowledge of the physiology of the normal human brain and its change...
As fMRI technology has provided invaluable insights into the mechanisms through which the human brain works in healthy individuals and in patients ...
to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think...
to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric dis...
to the Animal Models Volumes This volume describes animal models of drug addiction. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface in order to indicate why we think further research using animals is necessary. Animals should only be used when suitable alternatives are not available, and humans can only be experimented upon in severely proscribed circumstances. Alternative procedures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of...
to the Animal Models Volumes This volume describes animal models of drug addiction. Because of increasing public concern over the ethical treatment of...
In April 1982, an infant boy was born in Bloomington, Indiana, with Down syndrome and a defective, but surgically correctable, esophagus. His parents refused to consent to surgery or intravenous feeding. The hospital unsuccessfully sought a court order to force treatment, and appeals to higher courts also failed. The child, identified as Baby Doe by the news media, subsequently died. The events in Bloomington became the catalyst for action by the Reagan administration, the courts, and Congress that culminated in a federal policy that makes failure to treat newborns with disabilities a form of...
In April 1982, an infant boy was born in Bloomington, Indiana, with Down syndrome and a defective, but surgically correctable, esophagus. His parents ...
Most cells will survive removal from the natural mic- environment of their in vivo tissue and placement into a sterile culture dish under optimal conditions. Not only do they survive, but they also multiply and express differen- ated properties in such a culture dish. A few cells do this in suspension, but most will need some kind of mechanical support substituting for their natural connections with other cells. The surface of a culture dish that might have to be coated is usually sufficient. The recent trend to standa- ization of conditions and the existence of commercial ent- prises with...
Most cells will survive removal from the natural mic- environment of their in vivo tissue and placement into a sterile culture dish under optimal cond...
