This challenging and innovative book examines the processes involved in the birth and development of new scientific ideas. The author has searched for strategies used by scientists for producing new theories, both those that yield a range of plausible hypotheses and ones that aid in narrowing that range. She goes on to focus on the development of the theory of the gene as a case study in scientific creativity. Her discussion of modern genetics greatly demystifies the philosophy of science, and establishes a realistic framework for understanding how scientists actually go about their work....

This is the first volume of a comprehensive scientific biography of Hans Krebs, one of the world's foremost biochemists. It treats his childhood, his medical education and scientific apprenticeship under Otto Warburg, his emergence as an independent investigator, and his discovery of the urea cycle in 1932. This early achievement, and his discovery of the citric acid cycle, are viewed as foundations for the modern structure of intermediary metabolism. During the writing of this fascinating history, the author had access to a complete set of Krebs' laboratory notebooks that reveal the daily...

This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany,...