The field of biomedical research on alcoholism has developed at an unsurpassed speed in recent years. Today new medications and treatment strategies are available and new leads are currently tested in multi-center trials. This book gives a comprehensive overview about different neurotransmitter/peptide systems involved in relapse behavior. The editors - a basic preclinical researcher and a clinical researcher - and some of the most distinguished experts in the field compiled all new available preclinical and clinical data and offer a complete picture on modern relapse prevention. Without a...
The field of biomedical research on alcoholism has developed at an unsurpassed speed in recent years. Today new medications and treatment strategies a...
This topical volume provides an overview of clinically relevant data on anticancer agents. It is not only intended medical doctors working with cancer patients, and for medical researchers and students. The different classes of anticancer drugs are described by international authorities on the various topics. Apart from new targets for anticancer agents, attention is also focused on improving efficacy and tolerability of existing compounds.
This topical volume provides an overview of clinically relevant data on anticancer agents. It is not only intended medical doctors working with can...
Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders...
Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of th...
The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill ness, it allowed, for the first time, to adequately control the severe hallu cinations and delusional beliefs which prevent these patients from leading a more or less independent life. Indeed these antipsychotics (and the many congeners that were to follow) significantly reduced the number ofchronic schizophrenic inpatients in psychiatric clinics all over the world....
The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients...
Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system...
Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication a...
For over thirty years the benzodiazepines monopolised not only the anxiolytic market but also clinical and animal research in anxiety. Indeed many animal tests developed since the 1960s have been optimised for the benzodiazepines and some programmes have even screened candidates as potential anxiolytics on their benzodiazepine-like side-effects rather than their anxiolytic activity. With the realisation of the drawbacks of the benzodiazepines, namely their potential for tolerance and dependency, there has been a renewed interest in alternative anxiolytics both from existing drugs such as the...
For over thirty years the benzodiazepines monopolised not only the anxiolytic market but also clinical and animal research in anxiety. Indeed many ani...
Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform...
Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previo...
This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is presented in this reference book, including ongoing research from several disparate groups about NO as endothelium-derived relaxing factor (EDRF) and also as a neurotransmitter for nerves innervating erectile tissue in mammals.
The development of sildenafil as an oral...
This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Fol...
The drugs named calcium channel blockers (CCBs) were initially termed cal cium antagonists (see Chapter 1). They are also designated as calcium entry blockers (CEBs), calcium blockers, calcium channel antagonists, calcium channel inhibitors (and in French anticalciques). As this is reported in several chapters of this book, their main effect is a blockade of calcium entry into cells through voltage operated calcium channels (VOCCs). Chemically related drugs, such as Bay K 8644, exert the opposite effect by increasing the proba bility of calcium channel opening. One of the subcommittees of the...
The drugs named calcium channel blockers (CCBs) were initially termed cal cium antagonists (see Chapter 1). They are also designated as calcium entry ...
The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are...
The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, ...
