Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and...
Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At...
Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in vitro perfusion of human placenta Abuse of alcohol, nicotine, morphine, and cocaine during pregnancy, their placental transfer and fetal growth retardation Placental transfer and fetal toxicities of environmental insecticides Placental...
Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time...
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in...
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors. This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide...
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses ...
Intended for medicinal chemists, pharmaceutical scientists, pharmacologists, immunologists, biochemists and microbiologists, this book provides both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It offers state-of-the-art approaches to pharmaceutical development, including biological technologies currently used by some of the world's foremost laboratories. Features include: discussion of new techniques; previously unpublished data; and extensive reference lists.
Intended for medicinal chemists, pharmaceutical scientists, pharmacologists, immunologists, biochemists and microbiologists, this book provides both a...
