With the increasing interest in the experimental and clinical application of molecular imaging many institutions create research groups or interdisciplinary centers focussing on the complex development process of this new methodology. The aim for this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach...
With the increasing interest in the experimental and clinical application of molecular imaging many institutions create research groups or interdis...
Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is...
Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansi...
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use...
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective e...
During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity,...
During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, ...
Today's manufacturing environment is characterised by significant change in the way it is able to respond to its business objectives. Companies now face new challenges to meet customer demands including greater flexibility, a wider range of products, higher quality, improved lead time, whilst maintaining _c.ompetitive prices. The changes manifest in each company will differ but, the trend is towards providing a leaner, more responsive organisation. This is reflected in the need for Information Technology (IT) systems to be more integrated across an enterprise and for the systems to be...
Today's manufacturing environment is characterised by significant change in the way it is able to respond to its business objectives. Companies now fa...
Dopamine was initially regarded as a mere precursor of noradrenaline, but has progressively gained its present status of a common target for major drug classes and a substrate for some basic functions and dysfunctions of the Central Nervous System. The scientific interest has shifted from typically motor areas of the striatum to traditionally limbic ones as the nucleus accumbens and its afferent areas, the prefrontal cortex, the hippocampal formation and the basolateral amygdala. This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and...
Dopamine was initially regarded as a mere precursor of noradrenaline, but has progressively gained its present status of a common target for major dru...
This monograph offers a comprehensive review of present knowledge of the structure and connections of the trigeminal nuclei in humans, and compares it to laboratory animal findings. The authors provide cytoarchitectural data from their own research, and trace trigeminal pathways in human material by means of the Nauta technique. In humans the trigeminal nuclear complex includes the motor nucleus, the principal sensory (pontine) nucleus, the spinal nucleus (subdivided into oral, interpolar and caudal nuclei), and the mesencephalic nucleus and several small nuclei. The supratrigeminal nucleus,...
This monograph offers a comprehensive review of present knowledge of the structure and connections of the trigeminal nuclei in humans, and compares it...
Due to their pronounced intraspecific variability and to difficulties in defining their evolutionary trends in mammalian phylogenies, peripheral blood vessels have been neglected in comparative studies. Supported by the Sonderforschungsbereich 89 (Car diology) of the Deutsche Forschungsgemeinschaft, we have reconstructed the ontoge of the blood vessels of the tree shrew, Tupaia belangeri, on the netic morphogenesis basis of a series of developmental stages. The arteries of the lower extremity are described and discussed here. Besides describing the morphogenesis of the arteries in Tupaia, it...
Due to their pronounced intraspecific variability and to difficulties in defining their evolutionary trends in mammalian phylogenies, peripheral blood...
A cover story of Business Week Magazine in January 1984 stated "Biotech Comes of Age." In February 1986, Venture Magazine had a cover article entitled "The Biotech Revolution is Here." This article went on to say "New Genetic Technologies Will Transform Our Lives." These announcements were made many years after the first biotechnology companies, such as Genentech, Cetus, Amgen and Biogen, were formed-to commercialize the "New Biology." . At the time of writing this book, there are over 1300 biotech companies developing new technologies or identifying potential biotech drugs. Most of these...
A cover story of Business Week Magazine in January 1984 stated "Biotech Comes of Age." In February 1986, Venture Magazine had a cover article entitled...
The technology of drug testing is rapidly advancing. This book brings together world renowned experts in the fields of pharmacology and physiology united with the common theme of describing methods, theoretical concepts and in vitro systems used to study drug receptor mechanisms and the action of drugs on receptors. The first section deals with the physiology and pharmacology of integrated natural systems, the second with the new theoretical ideas used to model receptor systems (i.e. the nature of efficacy, receptor activation) and the third with the new in vitro systems available for the...
The technology of drug testing is rapidly advancing. This book brings together world renowned experts in the fields of pharmacology and physiology uni...
