Fatty liver disease including nonalcoholic steatohepatitis (NASH) involves the ac- mulation of triglycerides in hepatocytes with necrosis, in?ammation, and often ?b- sis with progression to cirrhosis. The two-hit model summarizes the important early metabolic events leading to hepatocellular necrosis in NASH. In these proceedings, we present various new ?ndings and a review of NASH. The liver has an important role in nutritional homeostasis, and liver diseases lead to abnormalities in nutrient metabolism and to subsequent malnutrition, especially in patients with liver cirr- sis....
Fatty liver disease including nonalcoholic steatohepatitis (NASH) involves the ac- mulation of triglycerides in hepatocytes with necrosis, in?ammation...
Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into...
Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significant...
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellular carcinoma. Hepatitis C virus-related diseases are a serious concern both in developing countries and in Japan and the United States, where the number of patients is also in the millions. Therapeutic modalities recently developed in Japan, including interferon therapy and nutritional supportive therapy, are gaining worldwide acceptance. At this critical juncture, HCV and Related Liver Diseases presents new information on etiology,...
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellu...
Since the discovery of superoxide dismutase more than three decades ago, there has been rapid growth in the knowledge of oxidative stress and disease. This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis. Also included are chapters on new aspects of oxidative stress and liver disease such as carbon monoxide as a regulator of liver...
Since the discovery of superoxide dismutase more than three decades ago, there has been rapid growth in the knowledge of oxidative stress and disea...
