To gain a better understanding of the pathology of liver disease, the signaling system controlling hepatocyte differentiation, proliferation, and apoptosis was selected as the theme of the 12th Yamaguchi Symposium on Liver Diseases. Ten leading researchers presented their latest experimental results. Focusing on apoptosis, guest speaker Professor D.A. Brenner, USA, spoke on the regulation of tumor necrosis factor alpha and Fas ligand-induced hepatic apoptosis by nerve factor-kappa B. Other researchers covered the molecular basis for clonal deletion therapy in hepatocellular carcinoma,...
To gain a better understanding of the pathology of liver disease, the signaling system controlling hepatocyte differentiation, proliferation, and apop...
The rise in hepatocellular carcinoma (HCC) mortality rates has caused researchers to focus increased attention on liver cirrhosis, a pathological condition known to lead to HCC. If hepatic fibrosis can be controlled, it follows that the risk of HCC among patients with chronic hepatitis can be reduced. In the quest for greater understanding of liver cirrhosis, the 1999 Yamaguchi Symposium on Liver Diseases brought together leading researchers in the field. Guest speakers included Michael J.P. Arthur, on mechanisms of the progression and regression of liver fibrosis; Mark A. Zern, on novel...
The rise in hepatocellular carcinoma (HCC) mortality rates has caused researchers to focus increased attention on liver cirrhosis, a pathological cond...
Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into...
Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significant...
The first single-topic annual conference on hepatology in Japan was held in November 2002 to discuss therapies for viral hepatitis and the prevention of hepatocellular carcinoma (HCC). Bringing together researchers and clinicians from North America, Europe, Japan, and other parts of Asia, the conference included symposia on the hepatitis C replicon system, new antivirals that lower or prevent the incidence of HCC, and transplantation in cases of hepatitis B and C, as well as new treatment modalities for viral hepatitis and preventative measures for HCC. With the rising number of HCC cases...
The first single-topic annual conference on hepatology in Japan was held in November 2002 to discuss therapies for viral hepatitis and the preventi...
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellular carcinoma. Hepatitis C virus-related diseases are a serious concern both in developing countries and in Japan and the United States, where the number of patients is also in the millions. Therapeutic modalities recently developed in Japan, including interferon therapy and nutritional supportive therapy, are gaining worldwide acceptance. At this critical juncture, HCV and Related Liver Diseases presents new information on etiology,...
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellu...
The rising incidence of hepatocellular cancer (HCC) is a cause for concern in all parts of the world today. Epidemiologists predict that HCC will become endemic because of the large numbers of carriers of hepatitis viruses that lead to the chronic liver diseases, which, in turn, are predisposing factors for the development of HCC. The eradication of HCC thus becomes an urgent priority. Against this background, Progress in HCC Treatment was the focus of the Yamaguchi (Japan) Symposium held in December 1998. Japanese hepatologists, unsurpassed in the diagnosis and treatment of HCC, were joined...
The rising incidence of hepatocellular cancer (HCC) is a cause for concern in all parts of the world today. Epidemiologists predict that HCC will beco...
Since the discovery of superoxide dismutase more than three decades ago, there has been rapid growth in the knowledge of oxidative stress and disease. This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis. Also included are chapters on new aspects of oxidative stress and liver disease such as carbon monoxide as a regulator of liver...
Since the discovery of superoxide dismutase more than three decades ago, there has been rapid growth in the knowledge of oxidative stress and disea...
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellular carcinoma. Hepatitis C virus-related diseases are a serious concern both in developing countries and in Japan and the United States, where the number of patients is also in the millions. Therapeutic modalities recently developed in Japan, including interferon therapy and nutritional supportive therapy, are gaining worldwide acceptance. At this critical juncture, HCV and Related Liver Diseases presents new information on etiology,...
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellu...
