The beginning of a new millennium is an ideal opportunity to look back, to contemplate the present and to envisage what the future might have to offer. This seems particularly appropriate for the rapidly developing field of hepatology. Therefore, the aim of the Falk Symposium 117, Hepatology 2000, held in Munich on 4-6 May 2000, was to offer state-of-the-art information on the most important aspects of hepatology and to discuss the challenges of the future. The presentations were given by experts in their respective areas, providing an update and at the same time incorporating the...
The beginning of a new millennium is an ideal opportunity to look back, to contemplate the present and to envisage what the future might have to offer...
In recent years, our knowledge about the pathogenesis, pathophysiology and treatment of hepatobiliary diseases has increased considerably. The molecular basis of cholestatic disorders as well as of gallstonedisease is increasingly recognized. This has resulted in improved diagnosis, for instance in hereditary forms of intrahepatic cholestasis, and advances in treatment, for example in primary biliary cirrhosis and otherchronic cholestatic disorders. This book, the proceedings of a Falk Workshop held in Cluj-Napoca, Romania, on June 9-10, 2000, brings together contributions from scientists and...
In recent years, our knowledge about the pathogenesis, pathophysiology and treatment of hepatobiliary diseases has increased considerably. The molecul...
There has been a tremendous amount of scientific progress in our understanding of the molecular mechanisms of transport processes in the liver within the last few years. Cloning of various members of organic anion and cation transporters has provided the necessary tools to study their regulation under physiological and pathophysiological conditions and has advanced our knowledge about bile formation. Mutations of various hepatic organic anion transporters have been identified in humans as hereditary defects leading to the heterogenous syndrome of progressive familial intrahepatic cholestasis...
There has been a tremendous amount of scientific progress in our understanding of the molecular mechanisms of transport processes in the liver within ...
This book is the proceedings of the Falk Symposium No. 122 on -Inflammatory Bowel Disease - A Clinical Case Approach to Pathophysiology, Diagnosis, and Treatment-, held in Bologna, Italy, on June 22-23, 2001, and deals with some major issues concerning Genetics of IBD, Pediatrics in IBD, Early vs Late IBD, Bacteria and Gut Inflammation, Refractory CD, Fistulizing CD, Refractory Distal Colitis, and Complications of Ileal-Pouch Anastomosis. The main aim of the meeting was to highlight the value of an integrated clinical approach and the importance of clinical research in developing innovative...
This book is the proceedings of the Falk Symposium No. 122 on -Inflammatory Bowel Disease - A Clinical Case Approach to Pathophysiology, Diagnosis, an...
This book, the proceedings of Falk Symposium No. 125 on 'Cytokines in Liver Injury and Repair' (Progress in Gastroenterology and Hepatology Part II), held in Hannover, Germany, on September 30 - October 1, 2001, provides an update of our current knowledge on the role of cytokines in various human and experimental liver diseases and on their present and prospective use in therapeutic trials.
Developments in recent years include: Since the first report of a cytokine knockout mouse for IL-2 in 1991 a large number of cytokine and cytokine receptor genes have been inactivated in mouse...
This book, the proceedings of Falk Symposium No. 125 on 'Cytokines in Liver Injury and Repair' (Progress in Gastroenterology and Hepatology Part II...
In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell...
In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despit...
This book is the proceedings of the Falk Symposium No. 127 on Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an...
This book is the proceedings of the Falk Symposium No. 127 on Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium ...
This book is the proceedings of Falk Symposium 128, held in Wurzburg, Germany, on May 2-3, 2002, and dedicated to the important issue of colonic carcinogenesis and its underlying genetic and environmental factors.
Colorectal cancer is one of the leading causes of cancer-related death in industrialized countries. It has been recognized to be the consequence of a dynamic process leading from hyperproliferative epithelium through different classes of adenomas to invasive carcinoma. This adenoma-carcinoma sequence has been characterized on a molecular basis. Modern molecular biology has...
This book is the proceedings of Falk Symposium 128, held in Wurzburg, Germany, on May 2-3, 2002, and dedicated to the important issue of colonic ca...
In gastrointestinal (GI) practice, a large proportion of patients present with what are currently classified as functional GI complaints. For decades, psychological causes have been implicated in the initiation and maintenance of symptoms. In recent years, disturbances of GI function including sensory motor abnormalities have been catalogued and are now believed to play a key role in the development of symptoms. A genetic predisposition may be important. Furthermore, evidence has accumulated that GI inflammation can trigger and maintains functional disturbances. In particular, acute GI...
In gastrointestinal (GI) practice, a large proportion of patients present with what are currently classified as functional GI complaints. For decad...
The first gene responsible for Crohn's disease has now been identified and the pathophysiological understanding of inflammatory bowel disease as well as its practical treatment have made much progress in recent years. Thus it is obviously important to consider the targets and the aims of treatment in context. The Falk Symposium No. 131 (Part II of the Gastroenterology Week Freiburg 2002), held in October 2002 in Freiburg, Germany, in its first part was dedicated to newly defined and partly alternative therapeutic targets. In addition, an attempt was made to learn from experts from other...
The first gene responsible for Crohn's disease has now been identified and the pathophysiological understanding of inflammatory bowel disease as well ...
