Hepatocyte Transplantation

ISBN-13: 9780792387763 / Angielski / Twarda / 2002 / 180 str.

S. Gupta; P. L. M. Jansen; J. Klempnauer

Opis

In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.

Spis treści

Preface. List of Contributors. Section I: Different Cell Types for Possible use in Transplantation. 1. Recent developments in the biology of liver stem cells; A.J. Strain, et al. Section II: Biological Mechanisms Concerning Transplanted Cells. 2. Transplantation of liver stem/progenitor cells; D.A. Shafritz, M.D. Dabeva. 3. Transplantation and differentiation of rat liver epithelial stem-like cells; W.B. Coleman, et al. 4. Co-transplantation of hepatocytes and non-parenchymal cells; H.J.F. Hodgson, et al. Section III: Mechanisms Concerning Repopulation of the Normal and Diseased Liver. 5. Cell transplantation into transgenic mice; J.A. Bezerra. 6. Liver repopulation by transplanted normal hepatocytes in a chemically preconditioned host; S. Laconi, et al. 7. Radiation-based approaches for liver repopulation; C. Guha, et al. Section IV: Cell Therapy of Acute Liver Failure and Chronic Liver Disease 8. Liver cell transplantation: human applications in adults and children; H. Soriano. Section V: Cell Therapy for Genetic Liver Diseases. 9. Transplantation of genetically engineered hepatocytes; J. Roy-Chowdhury, et al. 10. Hepatocyte transplantation and repopulation in a model of inherited cholestasis; R.P. Oude Elferink, et al. 11. Therapeutic liver repopulation strategies; C. Mitchell, et al. Section VI: Additional Considerations in Clinical Applications. 12. Human hepatocyte isolation from cadaver donor liver; F. Nakazawa, et al. 13. Assessment of shunting, portal haemodynamic changes and liver damage after intraportal infusion of [99m-Tc]macro-aggregated albumin (MAA)particles and hepatocytes in rabbits; M. Ott, et al. 14. Repopulation of diseased mouse liver with rodent and huma adult primary hepatocytes and long-term survival of transplanted hepatocytes in the upA/RAG-2 mouse model; M. Dandri, et al. Index.