New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually...
New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ...
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases." Such animal models should have impact not only on inflammatory dermatoses but...
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical deve...
Following its tradition of promoting novel areas of scienti?c discourse, the Ernst Schering Research Foundation (ESRF) hosted this workshop on chronic viral and in?ammatory cardiomyopathy. In late October 2004, scientists from Canada, Germany, the Georgian Republic, Great Britain, Italy, Japan, the Netherlands, Israel, Sweden, and the United States ga- ered in Berlin to discuss their concepts, hypotheses, and latest ?ndings on myocarditis and cardiomyopathy. This expert meeting was held in cooperation with the German - search Foundation, which in the same year had supported transregional...
Following its tradition of promoting novel areas of scienti?c discourse, the Ernst Schering Research Foundation (ESRF) hosted this workshop on chronic...
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering...
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. An...
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers - based on the (known) pharmacology of the drug and/or biology of the underlying disease - along with exposure-response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge,...
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., d...
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book...
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multiste...
A well written, readable and easily accessible introduction to "Choquet theory," which treats the representation of elements of a compact convex set as integral averages over extreme points of the set. The interest in this material arises both from its appealing geometrical nature as well as its extraordinarily wide range of application to areas ranging from approximation theory to ergodic theory. Many of these applications are treated in this book. This second edition is an expanded and updated version of what has become a classic basic reference in the subject.
A well written, readable and easily accessible introduction to "Choquet theory," which treats the representation of elements of a compact convex set a...
A logic-based approach to the design of computing systems would, undoubtedly, offer many advantages over the imperative paradigm most commonly applied so far for programming and hardware design and, consequently, logic, again and again, has been heralded as the basis for the next generation of computer systems. While logic and formal methods are indeed gaining ground in many areas of computer science and artificial intelligence the expected revolution has not yet happened. In this book the author offers a convincing solution to the ramification problem and qualification problem associated...
A logic-based approach to the design of computing systems would, undoubtedly, offer many advantages over the imperative paradigm most commonly applied...
This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology, orthopedics and infectious diseases. The book emphasizes clinical advances as proof of concept in cell therapy based on the revolutionizing observation that regeneration can occur throughout the body even in highly differentiated organs like the heart and the neuronal system. It provides examples of breakthroughs in the clinical implementation of adult stem cell therapy.
This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology,...
This volume constitutes the strictly refereed post-workshop proceedings of the Fourth International Workshop on Fast Software Encryption, FSE'97, held in Haifa, Israel, in January 1997. The 23 full papers presented were carefully selected from 44 submissions and revised for inclusion in the book. Also contained is a summary of a panel discussion. The papers are organized in sections on cryptanalysis, blockciphers, stream ciphers, message authentication codes, modes of operation, and fast software encryption. Particular emphasis is placed on applicability and implementation issues of fast...
This volume constitutes the strictly refereed post-workshop proceedings of the Fourth International Workshop on Fast Software Encryption, FSE'97, held...
