Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs 'work' medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable?
Drug Discovery opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process.
Co-written by Graham Lees and Tamas...
Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. E...
The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead Optimization scrutinizes these problems in detail, contrasting the promise of technology and industrialization with the challenges of using the tools available to their best advantage. The book explores early successes, examines the current state of the art, and provides a strategic analysis of the...
The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and...
The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs and their involvement in various human diseases.
The book presents current approaches in drug discovery that include target selection, establishment of screening and functional assays. It also covers recombinant GPCR expression for drug...
The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug dev...
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as biochips to reduce the cost of drug discovery and improve drug safety. The book explores the tools and skills required at each step of the discovery process when using biochips to determine biological outcomes.
The authors provide an in-depth...
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get...
Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical enterprise and outlines the specific technologies used at various stages of drug development. With contributions from leaders in academia, information technology, and the pharmaceutical industry, each chapter illustrates how a particular area of...
Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the bioph...
Book Description With multiwell assays for drug discovery becoming a staple of the scientific community, the Handbook of Assay Development in Drug Discovery provides general guidelines and specific examples of each assay system. It includes radiometric assays, fluorescent-based assays, and reporter assays for such targets as kinases, proteases, nuclear receptors, and GPCRs. It presents descriptions of methods, exact protocols used to perform such methods, and troubleshooting tools. Featuring contributions from assay developers in the pharmaceutical industry as well as the vendor community,...
Book Description With multiwell assays for drug discovery becoming a staple of the scientific community, the Handbook of Assay Development in Drug Dis...
The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures.
In Silico Technologies in Drug Target Identification and Validation addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating...
The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analy...
Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies.
The book provides readers with an overview of the amazing breadth of the impact that phage display technology has had on the study of proteins...
Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage...
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.
Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and...
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The eme...
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human...
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or pre...
