This book brings together key features of the toxicology and occupational hazards of pesticides and the way their use is regulated in the main trading regions of the world. There are chapters on each of the main groups of insecticides, namely organochlorines, anticholinesterases and pyrethrins and pyrethroids. The book also covers fungicides and herbicides, as well as more specialised agents such as microbial pesticides. The risks and hazards to humans are considered, both occupational and through the consumption of contaminated foodstuffs. Additionally, clinical aspects of pesticide...

This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:
* enzyme function in the metabolism and bioactivation of xenobiotics
* substrate specificity
* tissue distribution
* species distribution (to include laboratory animals and humans)
* hormonal regulation
* sex differences
* modulation by prior...

During the last decade the role of nutrition in toxicity and carcinogenicity has taken on greater importance. It has been recognized that food components, particularly of plant origin, have the potential to protect against cancer and heart disease, and these topics have received wide media attention. This volume discusses the mechanisms and current thinking of how nutritional status influences the way we respond to chemical insults and its role in the aetiology of disease. It takes a mechanistic approach to how dietary factors are related to toxicology and chemical carcinogenesis.

Heterocyclic amines (HCAs) are organic compounds comprising of carbon, hydrogen, and nitrogen in a ring structure. HCAs are believed to be cancer inducing, and are naturally-occurring compounds to which we are exposed to everyday.