This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include: * enzyme function in the metabolism and bioactivation of xenobiotics * substrate specificity * tissue distribution * species distribution (to include laboratory animals and humans) * hormonal regulation * sex differences * modulation by prior...
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs....
During the last decade the role of nutrition in toxicity and carcinogenicity has taken on greater importance. It has been recognized that food components, particularly of plant origin, have the potential to protect against cancer and heart disease, and these topics have received wide media attention. This volume discusses the mechanisms and current thinking of how nutritional status influences the way we respond to chemical insults and its role in the aetiology of disease. It takes a mechanistic approach to how dietary factors are related to toxicology and chemical carcinogenesis.
During the last decade the role of nutrition in toxicity and carcinogenicity has taken on greater importance. It has been recognized that food compone...
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme...
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contri...
