Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons.
Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma. They...

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this enzyme, mediating a suicidal mechanism triggered by DNA strand breakage. This hypothesis has since become a controversial centerpiece of the PARP field, with many experimental systems both confirming and extending the PARP suicide theory....

While the war on drugs continues to attract world attention, it is often overlooked that alcoholism remains a major worldwide health concern. No matter what your expertise, the CRC Handbook of Alcoholism can help you acquire the necessary skills to treat problem drinkers and alcohol-dependent patients.
In three sections - Patient Care, Research, and Useful Data and Definitions - this comprehensive handbook not only addresses the underlying psychological problems of alcoholism, but helps you to better diagnose and treat the nonpsychiatric medical disorders caused by the disease.

This volume examines the effects of chemicals on the peripheral nervous system and the subsequent changes in behaviour, with a focus on the toxicity of food components and behavioural effects of environmental toxicants. Topics covered include: acute and chronic effects; reversible and irreversible consequences; functional disorders of the nervous system; neurobehavioural dysfunctions; and the underlying neurobiological mechanisms.

Drugs of Abuse and Addiction: Neurobehavioral Toxicology examines drugs of abuse and addiction and how they affect behavior. This book considers the entire range of addiction research in humans and animals, using a multidisciplinary approach to discuss all areas of the neuro- and behavioral sciences involved. Emphasis is on acute and chronic effects; reversible and irreversible consequences, functional disorders of the nervous system; neurobehavioral dysfunctions; and the multi-sided aspects of adddiction and the underlying neurobiological mechanisms.

Circuit Simulation Methods and Algorithms provides a step-by-step theoretical consideration of methods, techniques, and algorithms in an easy-to-understand format. Many illustrations explain more difficult problems and present instructive circuits.
The book works on three levels:
The simulator-user level for practitioners and students who want to better understand circuit simulators.
The basic theoretical level, with examples, dedicated to students and beginning researchers.
The thorough level for deep insight into circuit simulation based on computer experiments using PSPICE...

The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date examination of new developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including

inflammatory and immune...

Examining various aspects of stealth liposomes, this book provides a historical perspective, describes liposome behavior in biological systems, and a reviews the role of glycolipid-containing liposome systems. It presents theoretical considerations followed by contributions that provide experimental verification of the various theoretical models.

Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointestinal tissues. This book covers neurochemistry, physiology, pharmacology, and clinical issues relevant to serotonin in the gastrointestinal tract. The editors have brought together the most relevant information from the molecular to the clinical level. Each chapter is written by investigators experienced in research on serotonin's actions in the gut. This book will be useful to basic scientists, clinical investigators, graduate and postgraduate...

Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness. With contributions by leading experts, this timely book includes chapters on how to evaluate theories of anesthesia in general and includes discussion of some of the techniques, such as genetics, that can be used to address problems. Also discussed are anesthetic actions at major brain targets with a special emphasis on ion channels and...