Brain edema is a simple phenomenon an abnormal increase of brain tissue volume by the increase of brain tissue water content. However the etiology is not simple and relating to a wide variety of neurological disorders including ischemia, trauma, tumor, hemorrhage and hydrocephalus. It is still a major cause of death in the neurological/neurosurgical ward. This volume is an up-to-date report on progress in brain edema research, diagnosis and treatment, including papers presented at the 12th International Symposium on Brain Edema and Brain Tissue Injury in 2002. Major topics include molecular...

Information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia. New aspects involve the endoplasmic reticulum, mitochondrial failure, pathobiology of axonal injury, molecular signals activating glial elements, or the emerging therapeutical role of neurotrophins. Experimental issues involve a better analysis of the ischemic penumbra, the salvagable tissue. Therapeutic contributions reach from the environmental influence to gene expression, including neuroprotection, such as hibernation mother nature s experiment or hypothermia which is...

This volume is the second in a new series of pro The task carried out through the collaboration of ceedings covering the official scientific meetings of the neurosurgeons and specialists in neurorehabilitation Neurorehabilitation Committee of the World Federa cannot be viewed simply as a restoration of function or tion of Neurosurgical Societies (WFNS). The first reconstruction of structure. Recent advances in neu scientific meeting of the WFNS Neurorehabilitation roimaging techniques have begun to demonstrate that Committee was held successfully in Munster, Ger it involves extensive...

Washington D. C., and at the Columbia University New York. In 1967 and 1968 he worked as a gen eral surgeon at the 1st Surgical Department of the Vienna Medical School with Professor Fuchsig. At the Max-Planck Institute in Munich he worked in the years 1968 to 1969 as a neuropathologist. In the year 1969 till 1972 back at the Department of Neurosurgery in Vienna he served as a general neurosurgeon and one of his main goals was pediatric neurosurgery. In Au gust 1972 he moved to Kiel to work with Professor Jensen at the Neurosurgical University Hospital. He had to graduate one more time in...

"Research" and "Publishing" are phrases familiar to all neurosurgeons and neuroscientists. Many young neurosurgeons struggle with them on a trial-and-error basis at first, and there are not structured education programs providing information on standard methods. The European Association of Neurosurgical Societies Research Committee has developed a course on research and publication methods for residents in neurosurgery who have not yet completed training. This supplement includes selected contributions from this course and will serve as an essential handbook providing basic tools to guide...

Quality in an invasive discipline such as neurosurgery comprises evidence based medicine, cost effectiveness and also risk control. Risk control and quality management have become a science on their own, combining the expertise of many specialists such as psychologists, mathematicians and also economists. Intensive communication with basic safety scientists as well as safety experts from the industry and traffic promises ideas and concepts than can be adopted for neurosurgery. An international conference was held in Munich in October 2000 bringing together neurosurgeons and safety experts...

Cerebral vasospasm remains a major clinical problem in patients with subarachnoid hemorrhage. Neuroprotection with calcium antagonists, hemodynamic therapy and interventional angioplasty have an established role in the management of this disease, but an effective single drug for prevention or treatment of the vasospasm is still lacking. This book contains selected contributions to the 7th International Conference on Cerebral Vasospasm held in Interlaken, Switzerland, in June 2000. Part I of the book concentrates on basic science and experimental vasospasm. The molecular biology of vasospasm,...

Brain edema is found in a wide variety of clinical disorders including stroke, intracerebral haemorrhage, subarachnoid haemorrhage, head injury, brain tumors and hydrocephalus. This volume brings together clinical and basic scientists from all over the world. Their expertise in the understanding of brain edema and shifts in brain water compartments has led to a further significant step in our understanding of those diseases characterized by brain edema. This book has also drawn on the expertise of the International Advisory Board of the Brain Edema Society, who have carefully summarized each...

In recent years much progress has been made in the field of neurochemi cal monitoring for the acutely injured brain. The development of safe continuous microdialysis techniques coupled with microanalytical metho dology can generate semi-continuous time profiles of the changes in nu merous brain analytes such as lactate, glucose, pyruvate, excitatory a mino acids, structural amino acids, indicators of free radical generat ion, cytokines, adenosine, and neuroprotective drugs. Descriptive stud ies have shown profound, prolonged, and severe abnormalities in many o f the analytes measured, and the...

The small neck of the aneurysm afforded an easy surgical attack. An ordinary flat silver clip was placed over the sac and tightly compressed obliterated it completely. The clip was flush with the wall of the carotid artery. The sac, lateral to the silver clip, was then picked up with the forceps and thrombosed by the electocautery. Walter Dandy reporting his successful operation of a posterior communicating aneurysm on March 23, 1937. Walter Dandy's patient left the hospital in good health 2 weeks later, and from his report one may gain the impression that the operation was an easy task....