In recent years much progress has been made in the field of neurochemi cal monitoring for the acutely injured brain. The development of safe continuous microdialysis techniques coupled with microanalytical metho dology can generate semi-continuous time profiles of the changes in nu merous brain analytes such as lactate, glucose, pyruvate, excitatory a mino acids, structural amino acids, indicators of free radical generat ion, cytokines, adenosine, and neuroprotective drugs. Descriptive stud ies have shown profound, prolonged, and severe abnormalities in many o f the analytes measured, and the...

This volume contains selected works from the 25th Anniversary of the International Conference on Intracranial Pressure (ICP) held in Williamsburg, Virginia. The theme of the meeting was Intracranial Pressure and Neuromonitoring and focused on all the current state of the art brain monitoring methodologies and their application to brain injury. The brain monitoring techniques covered a wide spectrum from neurochemical monitoring of the injured brain to specialized techniques for assessing shunt function in normal pressure hydrocephalus. It also includes the most recent advances in monitoring...