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This book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then...

Scroll shoulder tool is a relatively new friction stir welding (FSW) tool introduced by The Welding Institute of UK in 1999. It offers extra advantages of eliminating the tilted tool axis that is usually used in conventional tool FSW and performing non-linear thick section FSW with a relatively simple machine. However, the forming mechanism of its shoulder flow zone still remains unidentified. This mechanism is fundamental in designing a proper scroll shoulder tool to produce a defect-free weld. This monograph, firstly, systematically reviewed FSW tool design, weld zone material flow pattern...